COL18A1 ELISA 试剂盒
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- 抗原 See all COL18A1 ELISA试剂盒
- COL18A1 (Collagen, Type XVIII, alpha 1 (COL18A1))
- 抗原表位
- AA 1591-1774
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适用
- 大鼠
- 检测方法
- Colorimetric
- 实验类型
- Sandwich ELISA
- 应用范围
- ELISA
- 原理
- Sandwich High Sensitivity ELISA kit for Quantitative Detection of Rat Endostatin
- 品牌
- PicoKine™
- Analytical Method
- Quantitative
- 特异性
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Expression system for standard: NSO
Immunogen sequence: H1591-K1774 - 交叉反应 (详细)
- There is no detectable cross-reactivity with other relevant proteins.
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- 板类型
- Pre-coated
- 限制
- 仅限研究用
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- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
- 有效期
- 12 months
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- 抗原 See all COL18A1 ELISA试剂盒
- COL18A1 (Collagen, Type XVIII, alpha 1 (COL18A1))
- 别名
- Endostatin (COL18A1 产品)
- 别名
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- 物质类
- Chemical
- 背景
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Background: Endostatin is a naturally-occurring 20- kDa C-terminal fragment derived from type XVIII collagen. It is reported to serve as an anti-angiogenic agent, similar to angiostatin and thrombospondin. And It is produced by proteolytic cleavage of collagen XVIII, a member of the multiplexin family that is characterized by interruptions in the triple helix creating multiple domains, by proteases such as cathepsins. Using a genomic clone as a probe for fluorescence in situ hybridization, Endostatin was mapped the COL18A1 gene to 21q22.3. By immunoprecipitation analysis using membrane fractions of human mammary epithelial cells, It showed that endostatin specifically bound to cell surface nucleolin with high affinity. Blockage of nucleolin with neutralizing antibody or knockdown of nucleolin by RNA interference countered the antiendothelial activity of endostatin and abrogated its antiangiogenic and antitumor activity in vivo.
Synonyms: Collagen type XVIII, alpha (I) chain ,Col18a1 ,col18a1 ,
Full Gene Name: collagen, type XVIII, alpha 1
- UniProt
- Q9WUW5
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