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TGFA ELISA 试剂盒

TGFA 适用: 兔 AA 40-89 Colorimetric Sandwich ELISA
产品编号 ABIN5510564
发货至: 中国
  • 抗原 See all TGFA ELISA试剂盒
    TGFA (Transforming Growth Factor, alpha (TGFA))
    抗原表位
    AA 40-89
    适用
    • 11
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    检测方法
    Colorimetric
    实验类型
    Sandwich ELISA
    应用范围
    ELISA
    原理
    Sandwich High Sensitivity ELISA kit for Quantitative Detection of rabbit TGF alpha
    品牌
    PicoKine™
    Analytical Method
    Quantitative
    特异性
    Expression system for standard: E.coli,V40-A89
    交叉反应 (详细)
    There is cross-reactivity with TGF beta 2, TGF beta 3, TGF beta 5<1 % .
    产品特性

    Tissue Specificity: Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines. .

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  • 板类型
    Pre-coated
    限制
    仅限研究用
  • 储存条件
    4 °C,-20 °C
    储存方法
    Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
    有效期
    12 months
  • 抗原 See all TGFA ELISA试剂盒
    TGFA (Transforming Growth Factor, alpha (TGFA))
    别名
    TGFA (TGFA 产品)
    别名
    TFGA ELISA Kit, LOC100009482 ELISA Kit, TGF alpha ELISA Kit, TGFA ELISA Kit, wa-1 ELISA Kit, wa1 ELISA Kit, RATTGFAA ELISA Kit, TGFAA ELISA Kit, NV15606 ELISA Kit, si:ch211-10e8.7 ELISA Kit, transforming growth factor alpha ELISA Kit, transforming growth factor alpha L homeolog ELISA Kit, transforming growth factor-alpha ELISA Kit, transforming growth factor, alpha ELISA Kit, TGFA ELISA Kit, TGF-A ELISA Kit, Tgfa ELISA Kit, tgfa.L ELISA Kit, LOC100121300 ELISA Kit, LOC100009150 ELISA Kit, tgfa ELISA Kit
    背景

    Protein Function: TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.

    Background: Transforming growth factor alpha(TGF-alpha) is upregulated in some rabbit cancers. It is produced in macrophages, brain cells, and keratinocytes, and induces epithelial development. It is closely related to EGF, and can also bind to the EGF receptor with similar effects. TGFalpha stimulates neural cell proliferation in the adult injured brain. Transforming growth factor alpha gene(TGFA) maps to rabbit chromosome 2 close to the breakpoint of the t(2,8) variant translocation in Burkitt lymphoma. Synthetic TGF-alpha was as active as murine epidermal growth factor in binding to the epidermal growth factor receptor and in stimulation of anchorage-dependent and of anchorage-independent growth of normal indicator cells in culture. Synthetic TGF-alpha stimulated plasminogen activator production in A 431 and HeLa cells, the stimulation was similar to that induced by epidermal growth factor. Furthermore, synthetic rabbit TGF-alpha showed similar immunoreactivity when compared with rabbit TGF-alpha. Thus, the 50-amino acid TGF-alpha is likely to be the bioactive principle produced and secreted by tumor cell lines.

    Synonyms: Protransforming growth factor alpha,Transforming growth factor alpha,TGF-alpha,EGF-like TGF,ETGF,TGF type 1,TGFA,

    Full Gene Name: Protransforming growth factor alpha

    Cellular Localisation: Transforming growth factor alpha: Secreted, extracellular space.
    UniProt
    P01135
    途径
    NF-kappaB Signaling, RTK signaling, EGFR Signaling Pathway
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