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- 抗原 See all BACE2 试剂盒
- BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))
- 检测方法
- Fluorometric
- 应用范围
- Activation (Act), Fluorescence Resonance Energy Transfer Microscopy (FRET)
- 品牌
- SensoLyte®
- 产品特性
- The SensoLyte® 520 BACE2 Assay Kit is a homogeneous assay that can be used to detect the activity of enzyme and for screening of BACE2 inhibitors. It contains a QXL™ 520/5-FAM FRET substrate, derived from a peptide sequence surrounding cleavage site of BACE2. QXL™ 520 quenches 5-FAM fluorescence in the intact FRET peptide. Active BACE2 cleaves FRET substrate into two separate fragments resulting in the release of 5-FAM fluorescence that can be monitored at excitation /emission= 490/520 nm. The long wavelength fluorescence of 5-FAM is less interfered by the autofluorescence of components in biological samples and test compounds.
- Top Product
- Discover our top product BACE2 ELISA Kit
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beta-Site APP-Cleaving Enzyme 2 (BACE2) ELISA Kit
BACE2 适用: 人 Colorimetric Sandwich ELISA 0.156 ng/mL - 10 ng/mL Plasma, Serum, Tissue Homogenate
beta-Site APP-Cleaving Enzyme 2 (BACE2) ELISA KitBACE2 适用: 大鼠 Colorimetric Sandwich ELISA 0.156 ng/mL - 10 ng/mL Plasma, Serum, Tissue Homogenate
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- 说明
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FRET-based Assay Kit
- 限制
- 仅限研究用
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- 注意事项
- Protect Components A, B, and D from light and moisture.
- 储存条件
- -20 °C
- 储存方法
- Store all kit components at -20 °C Component C can be stored at 4 °C for convenience.
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- 抗原
- BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))
- 别名
- BACE2 (BACE2 产品)
- 别名
- AEPLC Kit, ALP56 Kit, ASP1 Kit, ASP21 Kit, BAE2 Kit, CEAP1 Kit, DRAP Kit, 1110059C24Rik Kit, AI850424 Kit, ARP1 Kit, CDA13 Kit, beta-site APP-cleaving enzyme 2 Kit, BACE2 Kit, Bace2 Kit
- 背景
- BACE2 (beta-Secretase-2, Memapsin-1) belongs to the family of transmembrane aspartic proteases. BACE2 has approximately 75 % homology with BACE1 (beta-Secretase-1) and is similar to the enzyme that cleaves Amyloid Precursor Protein (APP) at the beta-site, generating N-terminal part of beta-Amyloid peptide. Unlike BACE1, which is highly expressed in pancreas and brain tissue, BACE2 is more widespread and can be found in many peripheral tissues and at higher levels compared to BACE1. BACE2 is one of the highest efficiency beta-amyloid peptide degrading enzymes that is less active compared to insulin degrading enzyme (IDE). Therefore, targeting BACE2 is considered a potential therapeutic strategy for the prevention and treatment of Alzheimer's disease.
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