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ACA-IgA ELISA 试剂盒

ACA-IgA 适用: 人 Colorimetric Competition ELISA Serum
产品编号 ABIN1326803
发货至: 中国
  • 抗原 See all ACA-IgA products
    ACA-IgA (Anti-Cardiolipin Antibody IgA (ACA-IgA))
    适用
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    检测方法
    Colorimetric
    实验类型
    Competition ELISA
    应用范围
    ELISA
    原理
    Diluted patient serum is added to wells coated with purified aCL antigen. aCL specific IgA antibody, if present, binds to the antigen. All unbound materials are washed away and the enzyme conjugate is added to bind to the antibody-antigen complex, if present. Excess enzyme conjugate is washed off and substrate is added. The plate is incubated to allow the hydrolysis of the substrate by the enzyme. The intensity of the color generated is proportional to the amount of specific antibody in the sample.
    样品类型
    Serum
    Analytical Method
    Qualitative
  • 板类型
    Pre-coated
    限制
    仅限研究用
  • 储存条件
    4 °C
  • 抗原 See all ACA-IgA products
    ACA-IgA (Anti-Cardiolipin Antibody IgA (ACA-IgA))
    别名
    Cardiolipin IgA (ACA-IgA 产品)
    物质类
    Antibody
    背景
    Measurement of IgG, IgM and IgA cardiolipin autoantibodies (aCL) by EIA is the standard procedure for the detection of antiphospholipid antibodies (aPL) in patients with suspected antiphospholipid syndrome (APS).High aCL concentrations are associated with increased risk of venous and arterial thrombosis, recurrent pregnancy loss and thrombocytopenia. Patients with the anti-cardiolipin syndrome have one of the above clinical features and have antibodies to cardiolipin andor a positive lupus anticoagulant test. The antibodies present to cardiolipin may be of the IgG, IgA, IgM isotypes.Testing for the various antibody isotypes to cardiolipin aid in diagnosis of the anti-phospholipid syndrome in patients with SLE or lupus-like disorders. Binding of aCL to CL in patients with autoimmune diseases is dependent on the presence of the cofactor ibetai-2-glycoprotein I (ibetasub2subi-GPI) this binding is independent of ibetai-2-GPI in patients with infectious diseases (e.g., syphilis, tuberculosis). Recognition of the role of ibetai-2-GPI in the binding of aCL led to development of assay for direct measurement of ibetai-2-GPI autoantibodies using ibetai-2-GPI as antigen,allowing a clear distinction between ibetai-2-GPI autoantibodies and those that bind to CL alone.
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