KIR2DS4 抗体
(Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 4 (KIR2DS4))
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules\; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008].
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KIR2DS4 抗体 by 适用
Find KIR2DS4 抗体 for a variety of species such as anti-Human KIR2DS4. The species listed below are among those available. Click on a link to go to the corresponding products.
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Latest Publications for our KIR2DS4 抗体
: "Human NK cell receptor KIR2DS4 detects a conserved bacterial epitope presented by HLA-C." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, Issue 26, pp. 12964-12973, (2019) (PubMed).: "Activating KIR2DS4 Is Expressed by Uterine NK Cells and Contributes to Successful Pregnancy." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 197, Issue 11, pp. 4292-4300, (2017) (PubMed).
: "2DL1, 2DL2 and 2DL3 all contribute to KIR phenotype variability on human NK cells." in: Genes and immunity, Vol. 16, Issue 5, pp. 301-10, (2015) (PubMed).
: "Detection and significance of cytotoxic cell subsets in biopsies of HCV-infected human livers." in: Archivum immunologiae et therapiae experimentalis, Vol. 62, Issue 2, pp. 153-60, (2014) (PubMed).
: "CMV drives clonal expansion of NKG2C+ NK cells expressing self-specific KIRs in chronic hepatitis patients." in: European journal of immunology, Vol. 42, Issue 2, pp. 447-57, (2012) (PubMed).
: "NK cell terminal differentiation: correlated stepwise decrease of NKG2A and acquisition of KIRs." in: PLoS ONE, Vol. 5, Issue 8, pp. e11966, (2010) (PubMed).
Aliases for KIR2DS4 抗体
killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4 (KIR2DS4) 抗体CD158I 抗体
KIR1D 抗体
KIR412 抗体
KKA3 抗体
NKAT8 抗体
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