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KDM5A 产品

(Lysine (K)-Specific Demethylase 5A (KDM5A))

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The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein which regulates cell proliferation. This protein also interacts with rhombotin-2 which functions distinctly in erythropoiesis and in T-cell leukemogenesis. Rhombotin-2 is thought to either directly affect the activity of the encoded protein or may indirectly modulate the functions of the retinoblastoma protein by binding to this protein. [provided by RefSeq, Mar 2010].

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Featured KDM5A Categories

KDM5A 抗体

High quality antibodies with extensive validation data.

KDM5A 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended KDM5A 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IF, FACS
Validations
  • (3)
  • (6)
Cat. No. ABIN3201015
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IP, ChIP
Validations
  • (4)
Cat. No. ABIN7268330
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (3)
Cat. No. ABIN562597
Quantity 100 μg
Datasheet Datasheet

Recommended KDM5A ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6975003
Quantity 96 tests
Datasheet Datasheet

Recommended KDM5A 蛋白

Product
Reactivity
Source
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Cat. No.
Quantity
Datasheet
Reactivity Human
Source Baculovirus
Validations
  • (3)
Cat. No. ABIN2669680
Quantity 20 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1308284
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Yeast
Validations
  • (1)
Cat. No. ABIN5713580
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our KDM5A Products

Mitsui, Yoshida, Shinoda, Matsumori, Tsujii, Tsuchida, Wada, Hasegawa, Ito, Mino, Onuki, Yoshida, Sasaki, Mizukami: "Identification of ryuvidine as a KDM5A inhibitor." in: Scientific reports, Vol. 9, Issue 1, pp. 9952, (2019) (PubMed).

Eid, Abdel-Rehim: "Vitamin C promotes pluripotency of human induced pluripotent stem cells via the histone demethylase JARID1A." in: Biological chemistry, Vol. 397, Issue 11, pp. 1205-1213, (2016) (PubMed).

Chai, Smith, Fitter, Mitchell, Pan, Ilicic, Maiti, Zakar, Madsen: "Increased progesterone receptor A expression in labouring human myometrium is associated with decreased promoter occupancy by the histone demethylase JARID1A." in: Molecular human reproduction, Vol. 20, Issue 5, pp. 442-53, (2014) (PubMed).

Ge, Li, Wang, Liu, Zhu, Björkholm, Gruber, Xu: "Chromatin remodeling: recruitment of histone demethylase RBP2 by Mad1 for transcriptional repression of a Myc target gene, telomerase reverse transcriptase." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 24, Issue 2, pp. 579-86, (2010) (PubMed).

Liefke, Oswald, Alvarado, Ferres-Marco, Mittler, Rodriguez, Dominguez, Borggrefe: "Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex." in: Genes & development, Vol. 24, Issue 6, pp. 590-601, (2010) (PubMed).

Lopez-Bigas, Kisiel, Dewaal, Holmes, Volkert, Gupta, Love, Murray, Young, Benevolenskaya: "Genome-wide analysis of the H3K4 histone demethylase RBP2 reveals a transcriptional program controlling differentiation." in: Molecular cell, Vol. 31, Issue 4, pp. 520-30, (2008) (PubMed).

Tsai, Nguyen, Shi, Barton: "p53-targeted LSD1 functions in repression of chromatin structure and transcription in vivo." in: Molecular and cellular biology, Vol. 28, Issue 17, pp. 5139-46, (2008) (PubMed).

Christensen, Agger, Cloos, Pasini, Rose, Sennels, Rappsilber, Hansen, Salcini, Helin: "RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3." in: Cell, Vol. 128, Issue 6, pp. 1063-76, (2007) (PubMed).

Klose, Yan, Tothova, Yamane, Erdjument-Bromage, Tempst, Gilliland, Zhang, Kaelin: "The retinoblastoma binding protein RBP2 is an H3K4 demethylase." in: Cell, Vol. 128, Issue 5, pp. 889-900, (2007) (PubMed).

Synonyms and alternative names related to KDM5A

lysine demethylase 5A (Kdm5a), lysine demethylase 5A (KDM5A), lysine (K)-specific demethylase 5A (Kdm5a), AA409370, C76986, Jarid1a, JARID1A, RBBP-2, RBBP2, Rbbp2, RBP2

Protein level used designations for KDM5A

  • jumonji, AT rich interactive domain 1A (Rbp2 like)
  • lysine-specific demethylase 5A
  • jumonji, AT rich interactive domain 1A
  • lysine (K)-specific demethylase 5A
  • JARID1A variant protein-like
  • jumonji AT-rich interactive domain 1A
  • retinoblastoma binding protein 2
  • Jumonji, AT rich interactive domain 1A (RBP2-like)
  • histone demethylase JARID1A
  • jumonji/ARID domain-containing protein 1A
  • RBBP-2
  • retinoblastoma-binding protein 2
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