KDM4C 产品
(Lysine (K)-Specific Demethylase 4C (KDM4C))
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This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009].
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Recommended KDM4C 抗体
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Recommended KDM4C 蛋白
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Latest Publications for our KDM4C Products
: "Cyclopamine tartrate, a modulator of hedgehog signaling and mitochondrial respiration, effectively arrests lung tumor growth and progression." in: Scientific reports, Vol. 9, Issue 1, pp. 1405, (2019) (PubMed).: "KDM4B is a coactivator of c-Jun and involved in gastric carcinogenesis." in: Cell death & disease, Vol. 10, Issue 2, pp. 68, (2019) (PubMed).
: "SHMT2 and the BRCC36/BRISC deubiquitinase regulate HIV-1 Tat K63-ubiquitylation and destruction by autophagy." in: PLoS pathogens, Vol. 14, Issue 5, pp. e1007071, (2018) (PubMed).
: "KDM4B and KDM4A promote endometrial cancer progression by regulating androgen receptor, c-myc, and p27kip1." in: Oncotarget, Vol. 6, Issue 31, pp. 31702-20, (2015) (PubMed).
: "Phospho-ΔNp63α/microRNA network modulates epigenetic regulatory enzymes in squamous cell carcinomas." in: Cell cycle (Georgetown, Tex.), Vol. 13, Issue 5, pp. 749-61, (2014) (PubMed).
: "Global gene repression by the steroid receptor coactivator SRC-1 promotes oncogenesis." in: Cancer research, Vol. 74, Issue 9, pp. 2533-44, (2014) (PubMed).
: "Hypoxia enhances the expression of prostate-specific antigen by modifying the quantity and catalytic activity of Jumonji C domain-containing histone demethylases." in: Carcinogenesis, Vol. 34, Issue 12, pp. 2706-15, (2013) (PubMed).
: "Kdm4b histone demethylase is a DNA damage response protein and confers a survival advantage following γ-irradiation." in: The Journal of biological chemistry, Vol. 288, Issue 29, pp. 21376-88, (2013) (PubMed).
: "IDH mutation impairs histone demethylation and results in a block to cell differentiation." in: Nature, Vol. 483, Issue 7390, pp. 474-8, (2012) (PubMed).
: "RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites." in: The EMBO journal, Vol. 31, Issue 8, pp. 1865-78, (2012) (PubMed).
Synonyms and alternative names related to KDM4C
lysine demethylase 4C (KDM4C), jumonji domain containing 2c (Jmjd2c), lysine demethylase 4C (kdm4c), lysine (K)-specific demethylase 4C (Kdm4c), lysine demethylase 4C (Kdm4c), 2410141F18Rik, AA517467, bA146B14.1, GASC1, Gasc1, JHDM3C, JMJD2C, Jmjd2c, TDRD14CProtein level used designations for KDM4C
- jumonji domain containing 2C
- lysine (K)-specific demethylase 4C
- jumonji domain containing 2c
- lysine-specific demethylase 4C
- lysine-specific demethylase 4C-like
- GASC-1 protein
- JmjC domain-containing histone demethylation protein 3C
- gene amplified in squamous cell carcinoma 1 protein
- jumonji domain-containing protein 2C
- tudor domain containing 14C
- gene amplified in squamous cell carcinoma 1
- jmjC domain-containing histone demethylation protein 3C
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