KDM2A 产品
(Lysine (K)-Specific Demethylase 2A (KDM2A))
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This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012].
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Recommended KDM2A 抗体
Product
Reactivity
Application
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Cat. No.
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Datasheet
Reactivity
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- (3)
Cat. No.
ABIN7193407
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Cat. No.
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Quantity
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Datasheet
Datasheet
Reactivity
Bat, Cow, Dog, Guinea Pig, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat, Xenopus laevis, Zebrafish (Danio rerio)
Application
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Validations
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Cat. No.
ABIN6736177
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Datasheet
Recommended KDM2A ELISA试剂盒
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Recommended KDM2A 蛋白
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Cat. No.
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Cat. No.
ABIN1353718
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Datasheet
Datasheet
Reactivity
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Source
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Validations
Cat. No.
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Datasheet
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Latest Publications for our KDM2A Products
: "HPV16 E7-induced upregulation of KDM2A promotes cervical cancer progression by regulating miR-132-radixin pathway." in: Journal of cellular physiology, (2018) (PubMed).: "Transcriptional repression of histone deacetylase 3 by the histone demethylase KDM2A is coupled to tumorigenicity of lung cancer cells." in: The Journal of biological chemistry, Vol. 289, Issue 11, pp. 7483-96, (2014) (PubMed).
: "KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling." in: The Journal of clinical investigation, Vol. 123, Issue 12, pp. 5231-46, (2013) (PubMed).
: "Histone demethylation by a family of JmjC domain-containing proteins." in: Nature, Vol. 439, Issue 7078, pp. 811-6, (2006) (PubMed).
: "Nucleolar proteome dynamics." in: Nature, Vol. 433, Issue 7021, pp. 77-83, (2005) (PubMed).
: "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 6, Issue 1, pp. 63-70, (1999) (PubMed).
Synonyms and alternative names related to KDM2A
lysine demethylase 2A (KDM2A), lysine (K)-specific demethylase 2A (Kdm2a), lysine demethylase 2A (Kdm2a), lysine (K)-specific demethylase 2Aa (kdm2aa), 5530401A10Rik, 100043628, AA589516, AW536790, Cxxc8, CXXC8, fb76b11, Fbl7, FBL7, Fbl11, FBL11, FBXL11, Fbxl11, Gm4560, Jhdm1, JHDM1A, Jhdm1a, KDM2A, lalina, LILINA, wu:fb76b11, wu:fj11c04, zgc:158441, zgc:158606Protein level used designations for KDM2A
- F-box and leucine-rich repeat protein 11
- jumonji C domain-containing histone demethylase 1A
- lysine-specific demethylase 2A
- F-box protein containing leucine repeats
- F-box/LRR-repeat protein 11
- [Histone-H3]-lysine-36 demethylase 1A
- jmjC domain-containing histone demethylation protein 1A
- lysine (K)-specific demethylase 2A
- CXXC-type zinc finger protein 8
- JmjC domain-containing histone demethylation protein 1B
- lysine (K)-specific demethylase 2B
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