KCNQ4 产品
(Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4 (KCNQ4))
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The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured KCNQ4 Categories
Recommended KCNQ4 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN3185286
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, IF, ICC, AA
Validations
- (3)
- (4)
Cat. No.
ABIN361768
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (4)
Cat. No.
ABIN563951
Quantity
100 μg
Datasheet
Datasheet
Recommended KCNQ4 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1308480
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3114004
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3130220
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our KCNQ4 Products
: "Guanylyl Cyclase A/cGMP Signaling Slows Hidden, Age- and Acoustic Trauma-Induced Hearing Loss." in: Frontiers in aging neuroscience, Vol. 12, pp. 83, (2020) (PubMed).: "Hair cell maturation is differentially regulated along the tonotopic axis of the mammalian cochlea." in: The Journal of physiology, Vol. 598, Issue 1, pp. 151-170, (2020) (PubMed).
: "GC-B Deficient Mice With Axon Bifurcation Loss Exhibit Compromised Auditory Processing." in: Frontiers in neural circuits, Vol. 12, pp. 65, (2019) (PubMed).
: "Expression and function of Kv7.4 channels in rat cardiac mitochondria: possible targets for cardioprotection." in: Cardiovascular research, Vol. 110, Issue 1, pp. 40-50, (2016) (PubMed).
: "Role of Kv7 channels in responses of the pulmonary circulation to hypoxia." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 308, Issue 1, pp. L48-57, (2015) (PubMed).
: "K(V)7.4 channels participate in the control of rodent renal vascular resting tone." in: Acta physiologica (Oxford, England), Vol. 214, Issue 3, pp. 402-14, (2015) (PubMed).
: "Kv 7 positive modulators reduce detrusor overactivity and increase bladder capacity in rats." in: Basic & clinical pharmacology & toxicology, Vol. 110, Issue 2, pp. 145-53, (2014) (PubMed).
: "KCNQ and KCNE potassium channel subunit expression in bovine retinal pigment epithelium." in: Experimental eye research, Vol. 116, pp. 424-32, (2014) (PubMed).
: "The endocannabinoid 2-AG controls skeletal muscle cell differentiation via CB1 receptor-dependent inhibition of Kv7 channels." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 24, pp. E2472-81, (2014) (PubMed).
: "Specification of skeletal muscle differentiation by repressor element-1 silencing transcription factor (REST)-regulated Kv7.4 potassium channels." in: Molecular biology of the cell, Vol. 24, Issue 3, pp. 274-84, (2013) (PubMed).
Synonyms and alternative names related to KCNQ4
potassium voltage-gated channel subfamily Q member 4 (KCNQ4), potassium channel, voltage gated KQT-like subfamily Q, member 4 (kcnq4), potassium voltage-gated channel subfamily Q member 4 (Kcnq4), potassium voltage-gated channel, subfamily Q, member 4 (Kcnq4), DFNA2, DFNA2A, k(v)7.4, KCNQ4, kv7.4, KV7.4Protein level used designations for KCNQ4
- potassium voltage-gated channel, KQT-like subfamily, member 4
- potassium voltage-gated channel KQT-like protein 4
- potassium channel KQT-like 4
- potassium channel subunit alpha KvLQT4
- potassium voltage-gated channel subfamily KQT member 4
- KQT-like 4
- potassium voltage-gated channel, subfamily Q, member 4
- voltage-gated potassium channel subunit Kv7.4
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