KCNQ2 产品
(Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2))
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The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured KCNQ2 Categories
Recommended KCNQ2 抗体
Product
Reactivity
Application
Validations
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Quantity
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application
WB, IHC
Validations
- (4)
Cat. No.
ABIN2776303
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application
WB, IHC
Validations
- (2)
- (3)
Cat. No.
ABIN2776304
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Bat, Chicken, Cow, Dog, Guinea Pig, Horse, Human, Monkey, Mouse, Rat
Application
WB, IHC, IHC (p)
Validations
- (2)
Cat. No.
ABIN202417
Quantity
100 μL
Datasheet
Datasheet
Recommended KCNQ2 蛋白
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Source
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Human
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Wheat germ
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- (1)
Cat. No.
ABIN1308479
Quantity
2 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3110096
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3137656
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our KCNQ2 Products
: "Early-onset epileptic encephalopathy caused by gain-of-function mutations in the voltage sensor of Kv7.2 and Kv7.3 potassium channel subunits." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 9, pp. 3782-93, (2015) (PubMed).: "Epilepsy-causing mutations in Kv7.2 C-terminus affect binding and functional modulation by calmodulin." in: Biochimica et biophysica acta, Vol. 1852, Issue 9, pp. 1856-66, (2015) (PubMed).
: "K(V)7.4 channels participate in the control of rodent renal vascular resting tone." in: Acta physiologica (Oxford, England), Vol. 214, Issue 3, pp. 402-14, (2015) (PubMed).
: "Novel KCNQ2 and KCNQ3 mutations in a large cohort of families with benign neonatal epilepsy: first evidence for an altered channel regulation by syntaxin-1A." in: Human mutation, Vol. 35, Issue 3, pp. 356-67, (2014) (PubMed).
: "Polarized axonal surface expression of neuronal KCNQ potassium channels is regulated by calmodulin interaction with KCNQ2 subunit." in: PLoS ONE, Vol. 9, Issue 7, pp. e103655, (2014) (PubMed).
: "Membrane microdomain determines the specificity of receptor-mediated modulation of Kv7/M potassium currents." in: Neuroscience, Vol. 254, pp. 70-9, (2013) (PubMed).
: "Kv7/M-type potassium channels in rat skin keratinocytes." in: Pflügers Archiv : European journal of physiology, Vol. 465, Issue 9, pp. 1371-81, (2013) (PubMed).
: "Functional effects of KCNQ K(+) channels in airway smooth muscle." in: Frontiers in physiology, Vol. 4, pp. 277, (2013) (PubMed).
: "Developmental expression of Kv potassium channels at the axon initial segment of cultured hippocampal neurons." in: PLoS ONE, Vol. 7, Issue 10, pp. e48557, (2012) (PubMed).
: "Alterations in intrinsic membrane properties and the axon initial segment in a mouse model of Angelman syndrome." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, Issue 48, pp. 17637-48, (2011) (PubMed).
Synonyms and alternative names related to KCNQ2
potassium voltage-gated channel subfamily Q member 2 (KCNQ2), potassium voltage-gated channel, subfamily Q, member 2 (Kcnq2), potassium voltage-gated channel subfamily Q member 2 (Kcnq2), potassium voltage-gated channel subfamily KQT member 2 (LOC100537363), potassium voltage-gated channel, KQT-like subfamily, member 2a (kcnq2a), BFNC, BFNS1, EBN, EBN1, EIEE7, ENB1, HNSPC, KCNA11, KQT2, KV7.2, KVEBN1, mKQT2.3, mKQT2.4, Nmf134, zgc:171872Protein level used designations for KCNQ2
- KQT-like 2
- neuroblastoma-specific potassium channel protein
- neuroblastoma-specific potassium channel subunit alpha KvLQT2
- potassium voltage-gated channel subfamily KQT member 2
- voltage-gated potassium channel subunit Kv7.2
- potassium channel subunit alpha KvLQT2
- potassium voltage-gated channel, subfamily Q, member 2
- potassium voltage-gated channel KQT-like subfamily member 2.3
- potassium voltage-gated channel KQT-like subfamily member 2.4
- potassium voltage-gated channel, KQT-like subfamily, member 2
- LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily KQT member 2
- uncharacterized protein LOC100141342
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