KCNA3 产品
(Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3))
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Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq, Jul 2008].
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Featured KCNA3 Categories
Recommended KCNA3 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (5)
Cat. No.
ABIN561576
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IF, ICC, FACS, IP, LCI
Validations
- (5)
Cat. No.
ABIN7043521
Quantity
25 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7163952
Quantity
100 μL
Datasheet
Datasheet
Recommended KCNA3 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1308388
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3133115
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3113159
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our KCNA3 Products
: "Cell-free methods to produce structurally intact mammalian membrane proteins." in: Scientific reports, Vol. 6, pp. 30442, (2016) (PubMed).: "K+ channels expression in hypertension after arterial injury, and effect of selective Kv1.3 blockade with PAP-1 on intimal hyperplasia formation." in: Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy, Vol. 28, Issue 6, pp. 501-11, (2014) (PubMed).
: "Blockade of Kv1.3 channels ameliorates radiation-induced brain injury." in: Neuro-oncology, Vol. 16, Issue 4, pp. 528-39, (2014) (PubMed).
: "Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development." in: Journal of neuroscience research, Vol. 92, Issue 8, pp. 981-99, (2014) (PubMed).
: "Kv1.3 in psoriatic disease: PAP-1, a small molecule inhibitor of Kv1.3 is effective in the SCID mouse psoriasis--xenograft model." in: Journal of autoimmunity, Vol. 55, pp. 63-72, (2014) (PubMed).
: "Novel objective classification of reactive microglia following hypoglossal axotomy using hierarchical cluster analysis." in: The Journal of comparative neurology, Vol. 521, Issue 5, pp. 1184-201, (2013) (PubMed).
: "A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets." in: The Journal of physiology, Vol. 591, Issue Pt 7, pp. 1771-91, (2013) (PubMed).
: "Expression of Kv1.3 potassium channels regulates density of cortical interneurons." in: Developmental neurobiology, Vol. 73, Issue 11, pp. 841-55, (2013) (PubMed).
: "Kv1.3 inhibitors have differential effects on glucose uptake and AMPK activity in skeletal muscle cell lines and mouse ex vivo skeletal muscle." in: The journal of physiological sciences : JPS, Vol. 64, Issue 1, pp. 13-20, (2013) (PubMed).
: "Increased Kv1 channel expression may contribute to decreased sIPSC frequency following chronic inhibition of NR2B-containing NMDAR." in: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Vol. 37, Issue 6, pp. 1338-56, (2012) (PubMed).
Synonyms and alternative names related to KCNA3
potassium voltage-gated channel subfamily A member 3 (KCNA3), potassium channel, voltage gated shaker related subfamily A, member 3 S homeolog (kcna3.S), potassium voltage-gated channel, shaker-related subfamily, member 3 (Kcna3), potassium voltage-gated channel subfamily A member 3 (Kcna3), cKv1.1, HGK5, HLK3, HPCN3, HUKIII, Kca1-3, kcna3b-a, kv1.3, KV1.3, Kv1.3, Kv1.3-glyb, Kv1.3B, Mk-3, MK3, PCN3Protein level used designations for KCNA3
- glibenclamide-sensitive voltage-gated potassium channel
- potassium voltage-gated channel subfamily A member 3
- potassium voltage-gated channel, shaker-related subfamily, member 3
- shaker-like potassium channel subunit Kv1.3B
- potassium channel 3
- type n potassium channel
- voltage-gated K(+) channel HuKIII
- voltage-gated potassium channel protein Kv1.3
- voltage-gated potassium channel subunit Kv1.3
- MK3
- Voltage-gated potassium channel protein Kv1.3 (RGK5) (RCK3) (KV3)
- potassium voltage gated channel, shaker related subfamily, member 3
- KV3
- RCK3
- RGK5
- voltage-gated potassium channel subunit Kv3
- Shaker-like voltage-gated potassium channel cKv1.1
- shaker subfamily potassium channel Kv1.3 alpha subunit
- voltage-gated Kv1.3 potassium channel
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