KCNA2 产品
(Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 (KCNA2))
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Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1. [provided by RefSeq, Jul 2008].
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Featured KCNA2 Categories
Recommended KCNA2 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (2)
Cat. No.
ABIN6142695
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IF, ICC
Validations
- (3)
Cat. No.
ABIN7043517
Quantity
25 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
IF
Validations
- (1)
Cat. No.
ABIN7262100
Quantity
200 μL
Datasheet
Datasheet
Recommended KCNA2 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3112982
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3134601
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2724003
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our KCNA2 Products
: "Identification of a molecular locus for normalizing dysregulated GABA release from interneurons in the Fragile X brain." in: Molecular psychiatry, (2018) (PubMed).: "Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy." in: Nature medicine, Vol. 21, Issue 1, pp. 19-26, (2015) (PubMed).
: "Use-dependent activation of neuronal Kv1.2 channel complexes." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 8, pp. 3515-24, (2015) (PubMed).
: "De novo loss- or gain-of-function mutations in KCNA2 cause epileptic encephalopathy. ..." in: Nature genetics, Vol. 47, Issue 4, pp. 393-9, (2015) (PubMed).
: "Sialylation regulates brain structure and function." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 29, Issue 7, pp. 3040-53, (2015) (PubMed).
: "Human Neuroma-in-Continuity Contains Focal Deficits in Myelination." in: Journal of neuropathology and experimental neurology, Vol. 74, Issue 9, pp. 901-911, (2015) (PubMed).
: "Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes." in: The Journal of biological chemistry, Vol. 290, Issue 12, pp. 7918-29, (2015) (PubMed).
: "BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 18, pp. 7082-94, (2015) (PubMed).
: "Singular localization of sodium channel β4 subunit in unmyelinated fibres and its role in the striatum." in: Nature communications, Vol. 5, pp. 5525, (2014) (PubMed).
: "Ankyrin-G directly binds to kinesin-1 to transport voltage-gated Na+ channels into axons." in: Developmental cell, Vol. 28, Issue 2, pp. 117-31, (2014) (PubMed).
Synonyms and alternative names related to KCNA2
potassium voltage-gated channel subfamily A member 2 (KCNA2), potassium channel, voltage gated shaker related subfamily A, member 1 (kcna1), potassium voltage-gated channel, shaker-related subfamily, member 2 (Kcna2), potassium voltage-gated channel subfamily A member 2 (Kcna2), potassium voltage-gated channel subfamily A member 2 (LOC100537815), potassium channel, voltage gated shaker related subfamily A, member 2 S homeolog (kcna2.S), Akr6a4, BK2, ENSMUSG00000074335, Gm10672, HBK5, HK4, HUKIV, k(v)1.2, Kca1-2, KCNA2, kcna2, kcna2-a, KV1.2, Kv1.2, kv1.2, Mk-2, MK2, NGK1, RBK2, XSha2Protein level used designations for KCNA2
- potassium voltage-gated channel, shaker-related subfamily, member 2
- potassium voltage-gated channel subfamily A member 2-like
- potassium voltage-gated channel subfamily A member 2
- voltage-gated potassium channel Kv1.2
- shaker subfamily potassium channel Kv1.2 alpha subunit
- voltage-gated K(+) channel HuKIV
- voltage-gated potassium channel HBK5
- voltage-gated potassium channel protein Kv1.2
- voltage-gated potassium channel subunit Kv1.2
- MK2
- Potassium (K+) channel protein alpha 2, voltage dependent
- RAK
- RBK2
- RCK5
- potassium voltage gated channel shaker related subfamily member 2
- Kv1.2' potassium channel
- Voltage-gated potassium channel subunit Kv1.2
- potassium voltage-gated channel, shaker-related subfamily, member 2 a
- CSMK1
- delayed rectifier K+ channel
- voltage-dependent K channel
- voltage-gated channel, shaker-related subfamily, member 2
- potassium channel (BGK5)
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