JAK1 产品
(Janus Kinase 1 (JAK1))
Categories
Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. [provided by RefSeq, Jul 2008].
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Featured JAK1 Categories
JAK1 抗体
High quality antibodies with extensive validation data.
JAK1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
JAK1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended JAK1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, ELISA, IF, ICC
Validations
- (4)
- (12)
Cat. No.
ABIN6255762
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF, IHC (p)
Validations
- (4)
Cat. No.
ABIN7205612
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (4)
Cat. No.
ABIN7268038
Quantity
100 μL
Datasheet
Datasheet
Recommended JAK1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
- (3)
Cat. No.
ABIN1981723
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968075
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6962689
Quantity
96 tests
Datasheet
Datasheet
Recommended JAK1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1308275
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
Cat. No.
ABIN5508974
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7413241
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our JAK1 Products
: "Single-cell-level protein analysis revealing the roles of autoantigen-reactive B lymphocytes in autoimmune disease and the murine model." in: eLife, Vol. 10, (2021) (PubMed).: "Selective Janus Kinase 1 Inhibition Is a Promising Therapeutic Approach for Lupus Erythematosus Skin Lesions." in: Frontiers in immunology, Vol. 11, pp. 344, (2021) (PubMed).
: "In vivo and in vitro effects of microRNA-221 on hepatocellular carcinoma development and progression through the JAK-STAT3 signaling pathway by targeting SOCS3." in: Journal of cellular physiology, Vol. 234, Issue 4, pp. 3500-3514, (2019) (PubMed).
: "Combination of gemcitabine and erlotinib inhibits recurrent pancreatic cancer growth in mice via the JAK-STAT pathway." in: Oncology reports, Vol. 39, Issue 3, pp. 1081-1089, (2018) (PubMed).
: "A novel fluorinated triazole derivative suppresses macrophage activation and alleviates experimental colitis via a Twist1-dependent pathway." in: Biochemical pharmacology, Vol. 155, pp. 275-287, (2018) (PubMed).
: "Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK/STAT signaling pathway." in: International journal of molecular medicine, Vol. 41, Issue 4, pp. 1867-1876, (2018) (PubMed).
: "Lutein modulates transcription dysregulation of adhesion molecules and spermatogenesis transcription factors induced by testicular ischemia reperfusion injury: it could be SAFE." in: Naunyn-Schmiedeberg's archives of pharmacology, Vol. 389, Issue 5, pp. 539-51, (2017) (PubMed).
: "BCL2L10 inhibits growth and metastasis of hepatocellular carcinoma both in vitro and in vivo." in: Molecular carcinogenesis, Vol. 56, Issue 3, pp. 1137-1149, (2017) (PubMed).
: "Roflumilast reverses polymicrobial sepsis-induced liver damage by inhibiting inflammation in mice." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 97, Issue 9, pp. 1008-1019, (2017) (PubMed).
: "Enhancing NK cell-mediated cytotoxicity to cisplatin-resistant lung cancer cells via MEK/Erk signaling inhibition." in: Scientific reports, Vol. 7, Issue 1, pp. 7958, (2017) (PubMed).
Synonyms and alternative names related to JAK1
Janus kinase 1 (JAK1), Janus kinase 1 (Jak1), Janus kinase 1 (jak1), tyrosine-protein kinase JAK1 (LOC100286690), AA960307, C130039L05Rik, jak1, JAK1A, JAK1B, JTK3, wu:fb93e10Protein level used designations for JAK1
- tyrosine-protein kinase JAK1
- JAK-1
- etID309794.6
- fb93e10
- jak-1
- jak1 kinase
- Janus protein tyrosine kinase 1
- Janus kinase 1 (a protein tyrosine kinase)
- tyrosine kinase JAK1
- protein tyrosine kinase
- Janus kinase 1
- Tyrosine-protein kinase Jak1
- tyrosine-protein kinase JAK1-like
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