ITGAL (Efalizumab Biosimilar) 抗体
(ITGAL (Efalizumab Biosimilar))
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Recommended ITGAL (Efalizumab Biosimilar) 抗体
Synonyms and alternative names related to ITGAL (Efalizumab Biosimilar)
integrin subunit alpha L (ITGAL), CD11A, LFA-1, LFA1AProtein level used designations for ITGAL (Efalizumab Biosimilar)
- CD11 antigen-like family member A
- LFA-1 alpha
- LFA-1A
- antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide
- integrin alpha-L
- integrin gene promoter
- leukocyte adhesion glycoprotein LFA-1 alpha chain
- leukocyte function-associated molecule 1 alpha chain
- lymphocyte function-associated antigen 1
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