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IRS4 产品

(Insulin Receptor Substrate 4 (IRS4))
IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.. [provided by RefSeq, Jul 2008].

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Featured IRS4 Categories

IRS4 抗体

High quality antibodies with extensive validation data.

IRS4 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

IRS4 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended IRS4 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (3)
Cat. No. ABIN563643
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Application WB, ELISA, IF
Validations
  • (1)
  • (1)
Cat. No. ABIN5539610
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse, Rat
Application IF (cc), IF (p), ELISA, IHC (fro), IHC (p)
Validations
  • (1)
Cat. No. ABIN726020
Quantity 100 μL
Datasheet Datasheet

Recommended IRS4 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN454314
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN5592818
Quantity 96 tests
Datasheet Datasheet

Recommended IRS4 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1308110
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7419889
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7419892
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our IRS4 Products

Ikink, Boer, Bakker, Hilkens: "IRS4 induces mammary tumorigenesis and confers resistance to HER2-targeted therapy through constitutive PI3K/AKT-pathway hyperactivation." in: Nature communications, Vol. 7, pp. 13567, (2018) (PubMed).

Dearth, Cui, Kim, Hadsell, Lee: "Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2." in: Cell cycle (Georgetown, Tex.), Vol. 6, Issue 6, pp. 705-13, (2007) (PubMed).

White: "IRS proteins and the common path to diabetes." in: American journal of physiology. Endocrinology and metabolism, Vol. 283, Issue 3, pp. E413-22, (2002) (PubMed).

Burks, White: "IRS proteins and beta-cell function." in: Diabetes, Vol. 50 Suppl 1, pp. S140-5, (2001) (PubMed).

Synonyms and alternative names related to IRS4

insulin receptor substrate 4 (IRS4), insulin receptor substrate 4 (irs4), insulin receptor substrate 4 (Irs4), insulin receptor substrate 4 S homeolog (irs4.S), irs-4, IRS-4, irs2, irs2-a, IRS4, py160, PY160

Protein level used designations for IRS4

  • insulin receptor substrate 4
  • 160 kDa phosphotyrosine protein
  • phosphoprotein of 160 kDa
  • pp160
  • IRS-2-A
  • insulin receptor substrate 2-A
  • insulin receptor substrate protein
  • insulin receptor substrate-undetermined designation
  • insulin receptor substrate-unique
  • xIRS-u
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