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UNC-0379

Inh 1620401-82-2 6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)-pentyl)quinazolin-4-amine
产品编号 ABIN7233304
发货至: 中国
  • 应用范围
    Inhibition (Inh)
    原理
    SETD8 inhibitor
    产品特性
    UNC0379 is an inhibitor of the lysine methyltransferase SETD8 with selectivity over 15 other methyltransferases. IC50's = 7.3 μM in a radioactive methyl transfer assay and 9.0 μM in an MCE assay. UNC0379 treatment of SY5Y and NGP neuroblastoma cell lines lead to activation of p53 and decreased tumor growth in an ex-vivo tumorigenicity assay.
    纯度
    >98 %
    Chemical Name
    6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)-pentyl)quinazolin-4-amine
    Formula
    C23H35N5O2
    Solubility
    Soluble in DMSO (up to 30 mg/ml).
  • 限制
    仅限研究用
  • 状态
    Powder
    储存条件
    -20 °C
  • 背景
    Proliferation,Epigenetics,p53,Protein methyltransferase,Neuroscience,Cancer,Posttranslational modification,Chromatin
    分子量
    413.56
    CAS-编号
    1620401-82-2
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