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Tubastatin A HCl

Inh Cell-permeable 1310693-92-5 N-Hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride
产品编号 ABIN7233303
发货至: 中国
  • 应用范围
    Inhibition (Inh)
    原理
    HDAC6 inhibitor
    产品特性
    Potent and selective histone deacetylase 6 (HDAC6) inhibitor, IC50=15 nM (>1000-fold selective against other HDACs and 60-fold for HDAC8). Inhibits TNFα (IC50=272 nM) and IL-6 (IC50=712 nM) in LPS-stimulated human macrophages and displays anti-inflammatory activity in animal models. Improves survival in animal models of sepsis. Improves cognition in Alzheimers disease transgenic mice. Cell permeable.
    纯度
    >98 %
    Chemical Name
    N-Hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride
    Formula
    C20H22N3O2 • HCl
    Permeability
    Cell-permeable
    Solubility
    Soluble in DMSO (up to 50 mg/ml).
  • 限制
    仅限研究用
  • 状态
    Powder
    储存条件
    -20 °C
  • 背景
    Epigenetics,Protein deacetylase,Neuroscience,Neurodegeneration,Inflammation,Posttranslational modification,Chromatin
    分子量
    371.86
    CAS-编号
    1310693-92-5
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