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SRT1720 HCl

Act 1001645-58-4 N-[2-[3-(Piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide, hydrochloride
产品编号 ABIN7233295
发货至: 中国
  • 应用范围
    Activation (Act)
    原理
    SIRT1 activator
    产品特性
    Sirtuin1 (SIRT1) activator, EC1.5 = 0.16 μM, that reduces glucose levels and hyperinsulinemia in mouse and rat models of obesity. SRT1720 represses expression of circadian clock genes in vitro and in vivo. It inhibits vascular inflammation caused by angiotensin II-induced atherosclerosis and reverses abnormal mitochondrial function in primary neurons exposed to 20-HETE. Ameliorates hypoxic injury in pancreatic β-cells, and enhances ferroptosis in head and neck cancer cells.
    纯度
    >98 %
    Chemical Name
    N-[2-[3-(Piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide, hydrochloride
    Formula
    C25H23N7OS•HCl
    Solubility
    Soluble in DMSO (up to at least 25 mg/ml)
  • 限制
    仅限研究用
  • 状态
    Powder
    储存条件
    -20 °C
  • 背景
    SIRT 1933,Redox,Epigenetics,Apoptosis inhibitor,Mitochondrial function,Protein deacetylase,Oxidative stress,Cell death,Circadian rhythm,Diabetes,Kidney disease,Atherosclerosis,Inflammation,Posttranslational modification,Obesity,Chromatin
    分子量
    506.0
    CAS-编号
    1001645-58-4
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