Sirtinol
Quick Overview for Sirtinol (ABIN7233291)
应用范围
Chemical Name
Permeability
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原理
- SIRT inhibitor
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产品特性
- Inhibitor of sirtuin family enzymes including human SIRT1 (IC50=60μM), human SIRT2 (IC50=58μM), and yeast Sir2 (IC50=48μM) with no inhibition of human HDAC1. Active in vivo and in purified enzyme studies. Cell permeable.
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纯度
- >98 %
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Formula
- C26H22N2O2
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Solubility
- Soluble in DMSO (up to 30 mg/ml).
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Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
RadicicolInh 12772-57-5
Geldanamycin- FITCInh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
Anacardic AcidInh 16611-84-0 2-Hydroxy-6-pentadecylbenzoic acid
EX-527Inh Cell-permeable 49843-98-3 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic)
ResveratrolAct 501-36-0 3,4',5-Trihydroxy-trans-stilbene
5-AzacytidineInh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
NicotinamideInh 98-92-0 Pyridine-3-carboxylic acid amide
AS-8351Inh 796-42-9 2-Hydroxy-1-naphthylaldehyde isonicotinolyhydrazone
UNC-0379Inh 1620401-82-2 6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)-pentyl)quinazolin-4-amine
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限制
- 仅限研究用
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状态
- Powder
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注意事项
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GHS – Classification
Skin corrosion/irritation (Category 2), H315
Serious eye damage/eye irritation (Category 2A), H319
Specific target organ toxicity-single exposure (Category 3): Respiratory system, H335 -
储存条件
- -20 °C
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背景
- Epigenetics,Protein deacetylase,Stem cells,Posttranslational modification,Chromatin
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分子量
- 394.48
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CAS-编号
- 410536-97-9
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