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SirtAct (CAY-10591)

Inh 839699-72-8 2-Amino-N-cyclopentyl-1-(3-methoxypropyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide
产品编号 ABIN7233290
发货至: 中国
  • 应用范围
    Inhibition (Inh)
    原理
    SIRT1 activator
    产品特性
    Sirt1 activator (233 % at 10 μM)1 Suppresses TNFα release from THP-1 cells and stimulates adipogenesis in 3T3L1 cells. SIRT1 stimulation by SirtAct leads to decreased tissue factor mediated thrombogenicity in mice. Inhibits NFκB activation and reduces inflammatory cytokine production in lamina propria mononuclear cells from IBD patients. Prevents and cures experimental colitis in a mouse model.
    纯度
    >98 %
    Chemical Name
    2-Amino-N-cyclopentyl-1-(3-methoxypropyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide
    Formula
    C20H25N5O2
    Solubility
    Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 20 mg/ml).
  • 限制
    仅限研究用
  • 状态
    Powder
    储存条件
    -20 °C
  • 背景
    CAY10591,Posttranslational modification,Epigenetics,Chromatin,Protein deacetylase,Diabetes,Inflammation,Cytokine,NFkappaB
    分子量
    367.46
    CAS-编号
    839699-72-8
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