Santacruzamate A
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- 应用范围
- Inhibition (Inh)
- 原理
- Ultrapotent HDAC2 inhibitor
- 产品特性
- A highly potent and selective inhibitor of HDAC2 isolated from the Panamanian marine cyanobacterium cf. Symploca (IC50=0.119 and 434 nM for HDAC2 and HDAC6 respectively). Induces apoptosis and cancer cell death only in combination with other HDAC1 inhibitors. Potential therapeutic agent for breast cancer. Attenuates Aβ fragment (Aβ25-35)-induced toxicity in PC12 cells by enhancing ER stress tolerance. Ameliorates Alzheimer's disease-like pathology in mouse models.
- 纯度
- >98 %
- Chemical Name
- N-[4-Oxo-4-[(2-phenylethyl)amino]butyl]-carbamic acid, ethyl ester
- Formula
- C15H22N2O3
- Solubility
- Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml)
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Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
RadicicolInh 12772-57-5
Geldanamycin- FITCInh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
ResveratrolAct 501-36-0 3,4',5-Trihydroxy-trans-stilbene
PanobinostatInh 404950-80-7 (E)-N-Hydroxy-3-(4-((2-(2-methyl-1H-indol-3-yl)ethylamino)methyl)phenyl)acrylamide
HPA (Hexyl-4-pentynoic acid)Inh Cell-permeable 96017-59-3 2-(2-Propynyl)octanoic acid (racemic)
EX-527Inh Cell-permeable 49843-98-3 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic)
DaminozideInh 1596-84-5 1-(2,2-Dimethylhydrazide)butanedioic acid
Mithramycin AInh 18378-89-7
PiceatannolInh 10083-24-6 3,3',4,5'-Tetrahydroxy-trans-stilbene
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- 限制
- 仅限研究用
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- 状态
- Powder
- 注意事项
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GHS – Classification
Not a hazardous substance - 储存条件
- -20 °C
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- 背景
- Epigenetics,Posttranslational modification,Protein deacetylase,Neuroscience,Cell death,Cellular stress,Cancer,Neurodegeneration,Apoptosis inducer,Chromatin
- 分子量
- 278.35
- CAS-编号
- 1477949-42-0
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