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Remodelin

Inh 949912-58-7 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile
产品编号 ABIN7233278
发货至: 中国
  • 应用范围
    Inhibition (Inh)
    原理
    Acetyl-transferase NAT10 inhibitor
    产品特性
    Potent and selective inhibitor of N-acetyltransferase 10 (NAT10) which is capable of acetylating microtubules and histones. Improves nuclear architecture, chromatin organization and fitness of both human lamin A/C-depleted cells and Hutchinson-Gilford progeria syndrome patient cells, normalizing progeric and aging cells. Enhances health span in a mouse model of human accelerated aging syndrome. Significantly reduces many of the defects associated with accumulation of the lamin A precursor, prelamin A. Inhibits NAT10-promoted metastasis which may be mediated by endothelial-to-mesenchymal transition in hepatocellular carcinoma.
    纯度
    >98 %
    Chemical Name
    4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile
    Formula
    C15H14N4S
    Solubility
    Soluble in DMSO (up to 40 mg/ml)
  • 限制
    仅限研究用
  • 状态
    Powder
    储存条件
    -20 °C
  • 背景
    Epigenetics,Nuclear transport,Acetyltransferase,Cytoskeleton,Ageing,Posttranslational modification,Chromatin
    分子量
    282.36
    CAS-编号
    949912-58-7
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