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PFI-3

Inh Cell-permeable 1819363-80-8 (2E)-1-(2-Hydroxyphenyl)-3-[(1R,4R)-5-(pyridine-2-yl)-2,5-diazabicyclo{2.2.1]heptan-2-yl]prop-2-en-1-one
产品编号 ABIN7233275
发货至: 中国
  • 应用范围
    Inhibition (Inh)
    原理
    Bromodomain inhibitor
    产品特性
    PFI-3 is a selective inhibitor of family VIII bromodomains PB1(5), SMARCA2, and SMARCA4. It showed complete selectivity over all non-family VIII bromodomains. PFI-3 blocked adipogenesis in C3H10T1/2 mesenchymal cells at 20μM.Treatment of embryonic stem cells with PFI-3 led to deprivation of stemness and deregulated lineage specificity. Differentiation of trophoblast stem cells in the presence of PFI-3 was enhanced. Cell permeable.
    纯度
    >98 %
    Chemical Name
    (2E)-1-(2-Hydroxyphenyl)-3-[(1R,4R)-5-(pyridine-2-yl)-2,5-diazabicyclo{2.2.1]heptan-2-yl]prop-2-en-1-one
    Formula
    C19H19N3O2
    Permeability
    Cell-permeable
    Solubility
    Soluble in DMSO (up to at least 25 mg/ml)
  • 限制
    仅限研究用
  • 状态
    Powder
    储存条件
    -20 °C
  • 背景
    Epigenetics,Bromodomain,Stem Cells,Cancer,Posttranslational modification,Chromatin
    分子量
    321.4
    CAS-编号
    1819363-80-8
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