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PBIT

Inh 2514-30-9 2-(4-Methylphenyl)-1,2-benzisothiazol-3(2H)-one
产品编号 ABIN7233273
发货至: 中国
  • 应用范围
    Inhibition (Inh)
    原理
    JARID1 inhibitor
    产品特性
    The JARID1 (Jumonji AT-Rich Interactive Domain 1) family of lysine demethylases demethylates the trimethylated lysine 27 in histone H3 (H3K4me3). PBIT is a potent and selective inhibitor of JARID1 (IC50 = 3, 4.9 and 6 μM for JARID1B, 1A and 1C, respectively). Selective for JARID1 over UTX and JMJD3. Treatment of cells with PBIT inhibits the demethylation of H3K4me3. It inhibits proliferation of breast cancer cell lines expressing high levels of JARID1B1.
    纯度
    >98 %
    Chemical Name
    2-(4-Methylphenyl)-1,2-benzisothiazol-3(2H)-one
    Formula
    C14H11NOS
    Solubility
    Soluble in DMSO (up to 24 mg/ml) or in Ethanol (up to 5 mg/ml)
  • 限制
    仅限研究用
  • 状态
    Powder
    注意事项
    GHS – Classification
    Not a hazardous substance or mixture
    储存条件
    -20 °C
  • 背景
    Epigenetics,Proliferation,Protein demethylase,Vesicles,Cancer,Posttranslational modification,Chromatin
    分子量
    241.31
    CAS-编号
    2514-30-9
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