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MS-275

Inh 209783-80-2
产品编号 ABIN7233270
发货至: 中国
  • 应用范围
    Inhibition (Inh)
    原理
    HDAC inhibitor
    产品特性
    Potent HDAC inhibitor. Selective for HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 μM) and HDAC8 (IC50 > 100 μM). In vivo, MS-275 has been shown to inhibit tumor growth via induction of the tumor supressors p21WAF1/CIP1 and gelsolin and to block cell proliferation in a variety of cancer cell lines. The compound has also shown significant anti-rheumatic activity in rat and mouse arthritis models.
    纯度
    >98 %
    Formula
    C21H20N4O3
    Solubility
    Soluble in DMSO (up to 25 mg/ml).
  • 限制
    仅限研究用
  • 状态
    Powder
    储存条件
    -20 °C
  • 背景
    Entinostat,Epigenetics,Proliferation,Protein deacetylase,Inflammation,Cancer,Posttranslational modification,Chromatin
    分子量
    376.42
    CAS-编号
    209783-80-2
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