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JQ1 (+/-)

Inh 1268524-69-1 (6R,S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester
产品编号 ABIN7233265
发货至: 中国
  • 应用范围
    Inhibition (Inh)
    原理
    Bromodomain inhibitor
    产品特性
    JQ1 is a potent BET bromodomain inhibitor. IC50 = 17.7, 32.6, 76.9 and 12942 nM respectively for BRD2 (N-terminal (N)), BRD4 (C-terminal (C)), BRD4 (N) and CREBBP respectively. Competitive binding by JQ1 displaces the BRD4 fusion oncoprotein from chromatin, prompting squamous differentiation and specific antiproliferative effects in BRD4-dependent cell lines and patient-derived xenograft models establishing proof-of-concept for targeting protein-protein interactions of epigenetic readers.
    纯度
    >98 %
    Chemical Name
    (6R,S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester
    Formula
    C23H25ClN4O2S
    Solubility
    Soluble in DMSO (up to 9 mg/ml) or in Ethanol (up to 9 mg/ml) with warming.
  • 限制
    仅限研究用
  • 状态
    Powder
    注意事项
    GHS – Classification
    Pharmacologically active compound that has not been fully tested
    May be harmful if swallowed, inhaled or absorbed through skin
    Exposure may cause irritation to skin, eyes and upper respiratory tract
    Specific target organ toxicity - unknown
    储存条件
    RT
  • 背景
    Epigenetics,Proliferation,Bromodomain,Cancer,Posttranslational modification,Chromatin
    分子量
    457.00
    CAS-编号
    1268524-69-1
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