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JQ1 (+)

Inh 1268524-70-4 (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester
产品编号 ABIN7233264
发货至: 中国
  • 应用范围
    Inhibition (Inh)
    原理
    Bromodomain inhibitor
    产品特性
    JQ1 (+) is a potent BET bromodomain inhibitor and is the active isomer. IC50 = 17.7, 32.6, 76.9 and 12942 nM respectively for BRD2 (N-terminal (N)), BRD4 (C-terminal (C)), BRD4 (N) and CREBBP respectively (data for + isomer). Competitive binding by JQ1 displaces the BRD4 fusion oncoprotein from chromatin, prompting squamous differentiation and specific antiproliferative effects in BRD4-dependent cell lines and patient-derived xenograft models. Induces squamous differentiation in NMC cell lines and inhibits tumor growth in NMC xenografts. Displays reversible contraceptive effects in male mice. Blocks inflammation and bone loss in periodontitis. Reverses CAR T cell extinction.
    纯度
    >98 %
    Chemical Name
    (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester
    Formula
    C23H25ClN4O2S
    Solubility
    Soluble in DMSO (up to 60 mg/ml) or in Ethanol (up to 46 mg/ml)
  • 限制
    仅限研究用
  • 状态
    Powder
    注意事项
    GHS – Classification
    Not a hazardous substance or mixture
    储存条件
    RT
  • 背景
    Epigenetics,Proliferation,Bromodomain,Inflammation,Cancer,Posttranslational modification,Chromatin
    分子量
    457.0
    CAS-编号
    1268524-70-4
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