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JIB-04

Inh Cell-permeable 199596-05-9 (E)-5-Chloro-2-(2-(phenyl(pyridine-2-yl)methylene)hydrazinyl)pyridine
产品编号 ABIN7233263
发货至: 中国
  • 应用范围
    Inhibition (Inh)
    原理
    pan-JUMONJI histone demethylase inhibitor
    产品特性
    A novel specific inhibitor of the Jumonji family of histone demethylases in vitro, in cancer cells and in tumors in vivo. IC50 = 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively. Reduces tumor burden and prolongs life in a mouse model. Suppresses translation initiation and enhances mTOR inhibitor sensitivity. Inhibits the growth of temozolomide-resistant glioblastoma cells and crosses the blood brain barrier.
    纯度
    >98 %
    Chemical Name
    (E)-5-Chloro-2-(2-(phenyl(pyridine-2-yl)methylene)hydrazinyl)pyridine
    Formula
    C17H13ClN4
    Permeability
    Cell-permeable
    Solubility
    Soluble in DMSO (up to 30 mg/ml).
  • 限制
    仅限研究用
  • 状态
    Powder
    储存条件
    -20 °C
  • 背景
    Epigenetics,Posttranslational modification,Protein demethylase,Cancer,mTOR,Chromatin
    分子量
    308.76
    CAS-编号
    199596-05-9
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