电话:
+86 (0512) 65829739
传真:
+86 (010) 6788 5057
电子邮件:
orders@antibodies-online.cn

I-BET762

Inh 1260907-17-2 (4S)- 6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide
产品编号 ABIN7233261
发货至: 中国
  • 应用范围
    Inhibition (Inh)
    原理
    BET Bromodomain inhibitor, Suppresses Myc transcription
    产品特性
    I-BET762 is a potent inhibitor of the BET family of bromodomains with no activity at bromodomains BAZ2B, SP140, ATAD2, CREBBO, and PCAF. IC50's for H4Ac peptide displacement: BRD2 = 32.5nM, BRD3 = 42.4nM, BRD4 = 36.1nM. It was able to suppress proinflammatory proteins by macrophage, block acute inflammation in mice, and suppressed the inflammatory function of T cells. Inhibition of BET bromodomains results in downregulation of Myc transcription, an important oncogene.
    纯度
    >98 %
    Chemical Name
    (4S)- 6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide
    Formula
    C22H22ClN5O2
    Solubility
    Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml)
  • 限制
    仅限研究用
  • 状态
    Powder
    注意事项
    GHS – Classification
    Not a hazardous substance or mixture
    储存条件
    -20 °C
  • 背景
    GSK525762,Epigenetics,Bromodomain,Immunology,Inflammation,Cancer,Posttranslational modification,Chromatin
    分子量
    423.90
    CAS-编号
    1260907-17-2
You are here:
客服