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GSK-J1

Inh Not-permeable 1373422-53-7 N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine
产品编号 ABIN7233258
发货至: 中国
  • 应用范围
    Inhibition (Inh)
    原理
    JMJ H3K27 Demethylase inhibitor (cell impermeable)
    产品特性
    Potent and selective inhibitor of jumonji H3K27 histone demethylases JMJD3 and UTX (IC50 = 60 nM, human JMJD3). This is the first known inhibitor selective for the H3K27me3-specific JMJ subfamily which binds to the active catalytic site of the enzyme. The COOH group confers cell impermeability and as such is useful as a standard in in vitro assays. A cell permeable ethyl ester analog is also available.
    纯度
    >98 %
    Chemical Name
    N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine
    Formula
    C22H23N5O2
    Permeability
    Not-permeable
    Solubility
    Soluble in DMSO (up to 20 mg/ml).
  • 限制
    仅限研究用
  • 状态
    Powder
    储存条件
    RT
  • 背景
    Epigenetics,Protein demethylase,Posttranslational modification,Chromatin
    分子量
    389.46
    CAS-编号
    1373422-53-7
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