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Embelin

Inh Cell-permeable 550-24-3 2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione
产品编号 ABIN7233250
发货至: 中国
  • 应用范围
    Inhibition (Inh)
    原理
    XIAP inhibitor, Apoptosis inducer
    产品特性
    Inhibits the lysine acetyl transferase PCAF in vitro and in vivo (in vitro IC50=7.2 μM). Inhibits H3K9 acetylation in mouse liver tissue while leaving levels of H3K14, H4K8, H4K12 unchanged. Also inhibits X-linked inhibitor of apoptosis (XIAP) (IC50 = 4.1 μM, competing with Smac peptide). Binds to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Induces apoptosis and alters gene expression profiles in breast cancer cells. Possesses anti-inflammatory and analgesic activity in vivo. Cell-permeable.
    纯度
    >98 %
    Chemical Name
    2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione
    Formula
    C17H26O4
    Permeability
    Cell-permeable
    Solubility
    Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 3 mg/ml with warming)
  • 限制
    仅限研究用
  • 状态
    Powder
    储存条件
    -20 °C
  • 背景
    Epigenetics,Posttranslational modification,Acetyltransferase,Cell death,Inflammation,Cancer,Chromatin,Apoptosis inducer
    分子量
    294.39
    CAS-编号
    550-24-3
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