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CUDC-101

Inh 1012054-59-9 7-((4-((3-Ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide
产品编号 ABIN7233246
发货至: 中国
  • 应用范围
    Inhibition (Inh)
    原理
    Dual HDAC and EGFR inhibitor
    产品特性
    A novel hybrid dual-acting HDAC and receptor tyrosine kinase inhibitor. It is a potent HDAC inhibitor which also inhibits EGFR and HER2, IC50 = 4.4, 2.4 and 15.7 nM respectively. It not only blocks EGFR and HER2 but also attenuates multiple compensatory pathways such as AKT, HER3 and MET which enable tumor cells to escape the effects of conventional EGFR/HER2 inhibitors.
    纯度
    >98 %
    Chemical Name
    7-((4-((3-Ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide
    Formula
    C24H26N4O4
    Solubility
    Soluble in DMSO (up to 25 mg/ml)
  • 限制
    仅限研究用
  • 状态
    Powder
    储存条件
    -20 °C
  • 背景
    Epigenetics,Posttranslational modification,Kinase,Protein deacetylase,Cancer,Chromatin,AKT
    分子量
    434.49
    CAS-编号
    1012054-59-9
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