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Bosutinib (SKI-606)

Name: Bosutinib (SKI-606)
SKU: ABIN3220262
Availability: OutOfStock

InhA, Func 380843-75-4

产品编号 ABIN3220262

发货至: 中国

Datasheet as PDF

应用范围

Inhibition Assay (InhA), Functional Studies (Func)

原理

Bosutinib is a Bcr-Abl kinase inhibitor for the treatment of Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML). Compared to other tyrosine kinase inhibitors, it has a more favourable hematologic toxicity profile. FDA approved on September 4, 2012.

产品特性

Tradename: Bosutinib
Source of Compound: synthetic
Target: MAPK inhibitor,Src inhibitor,Bcr-Abl inhibitor,CaMK inhibitor,CDK inhibitor
Receptor: MAPKK2, MAPKKK2,ABL1, Lyn, HCK, Src,Breakpoint cluster region protein(BCR),Bcr-Abl ,CaMK,CDK 2

纯化方法

All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.

纯度

99 %

Formula

C26H29Cl2N5O3

Solubility

Soluble in DMSO
Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Radicicol
Inh 12772-57-5

Geldanamycin- FITC
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Panobinostat
Inh 404950-80-7 (E)-N-Hydroxy-3-(4-((2-(2-methyl-1H-indol-3-yl)ethylamino)methyl)phenyl)acrylamide

HPA (Hexyl-4-pentynoic acid)
Inh Cell-permeable 96017-59-3 2-(2-Propynyl)octanoic acid (racemic)

EX-527
Inh Cell-permeable 49843-98-3 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic)

Daminozide
Inh 1596-84-5 1-(2,2-Dimethylhydrazide)butanedioic acid

Mithramycin A
Inh 18378-89-7

Piceatannol
Inh 10083-24-6 3,3',4,5'-Tetrahydroxy-trans-stilbene

Santacruzamate A
Inh 1477949-42-0 N-[4-Oxo-4-[(2-phenylethyl)amino]butyl]-carbamic acid, ethyl ester

应用备注

Optimal working dilution should be determined by the investigator.

限制

仅限研究用
状态

Solid

储存条件

-20 °C

储存方法

For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.

有效期

24 months
背景

Cell cycle/Checkpoint,MAPK Signaling,Neuroscience,Tyrosine Kinase/Adaptors

分子量

530.45 g/mol

CAS-编号

380843-75-4