Crizotinib (PF-02341066)
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- 应用范围
- Inhibition Assay (InhA), Functional Studies (Func)
- 原理
- Crizotinib an inhibitor of receptor tyrosine kinase for the treatment of non-small cell lung cancer (NSCLC). Verification of the presence of ALK fusion gene is done by Abbott Molecular's Vysis ALK Break Apart FISH Probe Kit. This verification is used to select for patients suitable for treatment. FDA approved in August 26, 2011.
- 产品特性
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Tradename: XALKORI
Source of Compound: synthetic
Target: TGF-beta/Smad inhibitor,c-MET inhibitor
Receptor: ALK ,c-MET
- 纯化方法
- All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
- 纯度
- 99 % +
- Formula
- C21H22Cl2FN5O
- Solubility
- DMSO 9 mg/mL,Water <1 mg/mL
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Solid
- 储存条件
- -20 °C
- 储存方法
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For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours. - 有效期
- 24 months
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- 背景
- Tyrosine Kinase/Adaptors
- 分子量
- 450.34 g/mol
- CAS-编号
- 877399-52-5
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