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Geldanamycin

Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
产品编号 ABIN1027731
发货至: 中国
  • 应用范围
    Inhibition (Inh)
    原理
    Hsp90 inhibitor
    特异性
    Geldanamycin is a benzoquinoid ansamycin produced by Streptomyces hygroscopicus. It binds specifically to heat shock protein HSP90 and downregulates target proteins including tyrosine kinases, steroid receptors, transcription factors and cell cycle regulatory kinases. It induces the inactivation, destabilization and eventual degradation of HIF-1alpha. This is specifically a novel geldanamycin fluorescent probe that may be used in a fluorescence polarization assay for Hsp90 inhibitors. May also be used for detection of cell surface Hsp90. Other geldanamycin fluorophores (BODPY) have been reported and used in FP HTS assays.
    产品特性
    Hsp90 inhibitor.
    纯化方法
    Produced by fermentation
    纯度
    >95 %
    Chemical Name
    (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
    Formula
    C29H40N2O9
    Solubility
    Slightly soluble in methanol, chloroform or DMSO (10 mg/ml); insoluble in water
  • 说明

    Source: Produced by fermentation.
    Appearance: Yellow Solid

    限制
    仅限研究用
  • 状态
    Solid
    注意事项
    Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R68- Possible risk of irreversible effects
    注意事项
    Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R68- Possible risk of irreversible effects
    储存条件
    -20 °C
  • Cha, St Louis, Tradewell, Gentil, Minotti, Jaffer, Chen, Rubenstein, Durham: "A novel small molecule HSP90 inhibitor, NXD30001, differentially induces heat shock proteins in nervous tissue in culture and in vivo." in: Cell stress & chaperones, Vol. 19, Issue 3, pp. 421-35, (2014) (PubMed).

    Mori, Hitora, Nakamura, Yamagami, Horie, Nishimura, Yamamoto: "Hsp90 inhibitor induces autophagy and apoptosis in osteosarcoma cells." in: International journal of oncology, Vol. 46, Issue 1, pp. 47-54, (2014) (PubMed).

  • 分子量
    560.6
    CAS-编号
    30562-34-6
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