Inner Centromere Protein Antigens 135/155kDa 产品
(Inner Centromere Protein Antigens 135/155kDa (INCENP))
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In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A\; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143)\; MCAK (MIM 604538)\; KID (MIM 603213)\; cytoplasmic dynein (e.g., MIM 600112)\; CliPs (e.g., MIM 179838)\; and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM, Mar 2008].
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Inner Centromere Protein Antigens 135/155kDa 抗体
High quality antibodies with extensive validation data.
Inner Centromere Protein Antigens 135/155kDa 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Inner Centromere Protein Antigens 135/155kDa 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, FACS, ELISA, ICC, IHC
Validations
- (2)
- (7)
Cat. No.
ABIN969529
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, FACS, ELISA, IHC
Validations
- (7)
Cat. No.
ABIN1491465
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, FACS, ELISA, IHC, IF/ICC
Validations
- (8)
Cat. No.
ABIN1844019
Quantity
100 μL
Datasheet
Datasheet
Recommended Inner Centromere Protein Antigens 135/155kDa 蛋白
Product
Reactivity
Source
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Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Baculovirus infected Insect Cells, Insect cells (Sf9)
Validations
Cat. No.
ABIN6699954
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our Inner Centromere Protein Antigens 135/155kDa Products
: "Mitotic kinase Aurora-B is regulated by SUMO-2/3 conjugation/deconjugation during mitosis." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 16, Issue 6, pp. 652-69, (2011) (PubMed).: "Aurora B dynamics at centromeres create a diffusion-based phosphorylation gradient." in: The Journal of cell biology, Vol. 194, Issue 4, pp. 539-49, (2011) (PubMed).
: "INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization." in: The Journal of cell biology, Vol. 187, Issue 5, pp. 637-53, (2009) (PubMed).
Synonyms and alternative names related to Inner Centromere Protein Antigens 135/155kDa
inner centromere protein (INCENP), inner centromere protein (Incenp), inner centromere protein S homeolog (incenp.S), inner centromere protein (incenp), inner centromere protein L homeolog (incenp.L), 2700067E22Rik, AU019509, C77457, C130081E20, INCENP, incenp, incenp-a, incenp-b, LOC572121, xINC, xIncenp, XL-INCENP, xl-incenpProtein level used designations for Inner Centromere Protein Antigens 135/155kDa
- binds and activates aurora-B and -C in vivo and in vitro
- chromosomal passenger protein
- inner centromere protein
- inner centromere protein INCENP
- inner centromere protein antigens 135/155kDa
- class I INCENP protein
- class II INCENP protein
- inner centromere protein B
- similar to XL-INCENP
- inner centromere protein-like
- Mitotic phosphoprotein 130
- inner centromere protein A
- mitotic phosphoprotein 130
- xINC
- xIncenp
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