Inner Centromere Protein Antigens 135/155kDa 产品
(Inner Centromere Protein Antigens 135/155kDa (INCENP))
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In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A\; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143)\; MCAK (MIM 604538)\; KID (MIM 603213)\; cytoplasmic dynein (e.g., MIM 600112)\; CliPs (e.g., MIM 179838)\; and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM, Mar 2008].
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Inner Centromere Protein Antigens 135/155kDa 抗体
High quality antibodies with extensive validation data.
Inner Centromere Protein Antigens 135/155kDa 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Inner Centromere Protein Antigens 135/155kDa 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
FACS, ELISA, ICC, IHC
Validations
- (2)
- (7)
Cat. No.
ABIN969529
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, FACS, ELISA, IHC
Validations
- (7)
Cat. No.
ABIN1491465
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, FACS, ELISA, IHC, IF/ICC
Validations
- (8)
Cat. No.
ABIN1844019
Quantity
100 μL
Datasheet
Datasheet
Recommended Inner Centromere Protein Antigens 135/155kDa 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Baculovirus infected Insect Cells, Insect cells (Sf9)
Validations
Cat. No.
ABIN6699954
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our Inner Centromere Protein Antigens 135/155kDa Products
: "Mitotic kinase Aurora-B is regulated by SUMO-2/3 conjugation/deconjugation during mitosis." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 16, Issue 6, pp. 652-69, (2011) (PubMed).: "Aurora B dynamics at centromeres create a diffusion-based phosphorylation gradient." in: The Journal of cell biology, Vol. 194, Issue 4, pp. 539-49, (2011) (PubMed).
: "INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization." in: The Journal of cell biology, Vol. 187, Issue 5, pp. 637-53, (2009) (PubMed).
Synonyms and alternative names related to Inner Centromere Protein Antigens 135/155kDa
inner centromere protein (INCENP), inner centromere protein (Incenp), inner centromere protein S homeolog (incenp.S), inner centromere protein (incenp), inner centromere protein L homeolog (incenp.L), 2700067E22Rik, AU019509, C77457, C130081E20, INCENP, incenp, incenp-a, incenp-b, LOC572121, xINC, xIncenp, XL-INCENP, xl-incenpProtein level used designations for Inner Centromere Protein Antigens 135/155kDa
- binds and activates aurora-B and -C in vivo and in vitro
- chromosomal passenger protein
- inner centromere protein
- inner centromere protein INCENP
- inner centromere protein antigens 135/155kDa
- class I INCENP protein
- class II INCENP protein
- inner centromere protein B
- similar to XL-INCENP
- inner centromere protein-like
- Mitotic phosphoprotein 130
- inner centromere protein A
- mitotic phosphoprotein 130
- xINC
- xIncenp
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