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IMPA1 产品

(Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1))

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This gene encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Nov 2009].

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Featured IMPA1 Categories

IMPA1 抗体

High quality antibodies with extensive validation data.

IMPA1 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

IMPA1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended IMPA1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (11)
Cat. No. ABIN6142429
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, ELISA
Validations
  • (3)
Cat. No. ABIN7246232
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (2)
  • (1)
Cat. No. ABIN561484
Quantity 50 μL
Datasheet Datasheet

Recommended IMPA1 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6967605
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1138077
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method
Validations
Cat. No. ABIN1138079
Quantity 96 tests
Datasheet Datasheet

Recommended IMPA1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123442
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1307883
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7318620
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our IMPA1 Products

Andreassi, Zimmermann, Mitter, Fusco, De Vita, Devita, Saiardi, Riccio: "An NGF-responsive element targets myo-inositol monophosphatase-1 mRNA to sympathetic neuron axons." in: Nature neuroscience, Vol. 13, Issue 3, pp. 291-301, (2010) (PubMed).

van Nieuwenhuijzen, Kashem, Matsumoto, Hunt, McGregor: "A long hangover from party drugs: residual proteomic changes in the hippocampus of rats 8 weeks after ?-hydroxybutyrate (GHB), 3,4-methylenedioxymethamphetamine (MDMA) or their combination." in: Neurochemistry international, Vol. 56, Issue 8, pp. 871-7, (2010) (PubMed).

Synonyms and alternative names related to IMPA1

inositol monophosphatase 1 (impa1), inositol(myo)-1(or 4)-monophosphatase 1 (impa1), inositol (myo)-1(or 4)-monophosphatase 1 (Impa1), inositol monophosphatase 1 (Impa1), inositol monophosphatase (impa1), inositol monophosphatase 1 (IMPA1), inositol(myo)-1(or 4)-monophosphatase 1 S homeolog (impa1.S), inositol(myo)-1(or 4)-monophosphatase 1 (IMPA1), 2610002K09Rik, 2900059K10Rik, AI325909, IMP, IMPA, impa, zgc:100926

Protein level used designations for IMPA1

  • inositol monophosphatase 1
  • Inositol monophosphatase
  • IMP 1
  • IMPase 1
  • inositol-1(or 4)-monophosphatase 1
  • lithium-sensitive myo-inositol monophosphatase A1
  • myo-inositol monophosphatase
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