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IL12B 产品

(Interleukin 12 beta (IL12B))
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008].

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Featured IL12B Categories

IL12B 抗体

High quality antibodies with extensive validation data.

IL12B ELISA试剂盒

Reliable ELISA kits for a wide range of species.

IL12B 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended IL12B 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application WB, ELISA, ICC, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
  • (1)
  • (2)
Cat. No. ABIN2176964
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (3)
Cat. No. ABIN7428812
Quantity 100 μL
Datasheet Datasheet
Reactivity Sheep
Application WB, ELISA, IHC
Validations
  • (3)
Cat. No. ABIN7179323
Quantity 100 μg
Datasheet Datasheet

Recommended IL12B ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6957015
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6957017
Quantity 96 tests
Datasheet Datasheet
Reactivity Horse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6957011
Quantity 96 tests
Datasheet Datasheet

Recommended IL12B 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (4)
Cat. No. ABIN7275396
Quantity 100 μg
Datasheet Datasheet
Reactivity Cynomolgus
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN7275395
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana benthamiana)
Validations
  • (2)
Cat. No. ABIN1019696
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our IL12B Products

Xu, Wan, Lin, Su: "Effects of Early Intervention with Antibiotics and Maternal Fecal Microbiota on Transcriptomic Profiling Ileal Mucusa in Neonatal Pigs." in: Antibiotics (Basel, Switzerland), Vol. 9, Issue 1, (2020) (PubMed).

Zeng, Qiao, Lv, Fan, Liu, Xie: "High-dose dexamethasone induced LPS-stimulated rat alveolar macrophages apoptosis." in: Drug design, development and therapy, Vol. 11, pp. 3097-3104, (2018) (PubMed).

Li, Diao, Guo, Huang, Yang, Feng, Yan, Ning, Zheng, Chen, Wu: "VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism." in: Nature communications, Vol. 8, Issue 1, pp. 1322, (2018) (PubMed).

Du, Chen, Wang, Sun: "Pathway analysis of global gene expression change in dendritic cells induced by the polysaccharide from the roots of Actinidia eriantha." in: Journal of ethnopharmacology, Vol. 214, pp. 141-152, (2018) (PubMed).

Zhang, Yang, Li, Yang, Zhao, Wang, Wu: "Immunostimulatory activity of water-extractable polysaccharides from Cistanche deserticola as a plant adjuvant in vitro and in vivo." in: PLoS ONE, Vol. 13, Issue 1, pp. e0191356, (2018) (PubMed).

van der Vorst, Theodorou, Wu, Hoeksema, Goossens, Bursill, Aliyev, Huitema, Tas, Wolfs, Kuijpers, Gijbels, Schalkwijk, Koonen, Abdollahi-Roodsaz, McDaniels, Wang, Leitges, Lawrence, Plat, Van Eck et al.: "High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-κB/STAT1-IRF1 Signaling. ..." in: Cell metabolism, Vol. 25, Issue 1, pp. 197-207, (2017) (PubMed).

Goda, Khedr, Elshenawy, Ibrahim, El-Araby, Sira: "Preoperative Serum IL-12p40 Is a Potential Predictor of Kasai Portoenterostomy Outcome in Infants with Biliary Atresia." in: Gastroenterology research and practice, Vol. 2017, pp. 9089068, (2017) (PubMed).

Hamuti, Li, Zhou, Aipire, Ma, Yang, Li: "Capparis spinosa Fruit Ethanol Extracts Exert Different Effects on the Maturation of Dendritic Cells." in: Molecules (Basel, Switzerland), Vol. 22, Issue 1, (2017) (PubMed).

Hou, Zhu, Sun, Ma, Wang, Timothy, Chen, Yan, Lei, Han, Chen, Cai, Guan: "Serum Proteomics Analysis in Rats of Immunosuppression Induced by Chronic Stress." in: Scandinavian journal of immunology, Vol. 84, Issue 3, pp. 165-73, (2016) (PubMed).

Wen, Xiong, He, Zhang, Du, Liu, Wang, Zhou, Ma: "Fusion cytokine IL-2-GMCSF enhances anticancer immune responses through promoting cell-cell interactions." in: Journal of translational medicine, Vol. 14, pp. 41, (2016) (PubMed).

Synonyms and alternative names related to IL12B

interleukin 12B (IL12B), interleukin 12b (Il12b), interleukin 12B (Il12b), interleukin 12Ba (il12ba), CLMF, CLMF2, CLMF p40, IL-12, IL-12 p40, IL-12.p40, IL-12B, Il-12b, Il-12p40, IL-12p40, Il12, il12b, IL12B, Il12p40, IL12p40, il12p40.b, NKSF, NKSF2, p40, zgc:152789

Protein level used designations for IL12B

  • CLMF p40
  • IL-12 subunit p40
  • IL12, subunit p40
  • NK cell stimulatory factor chain 2
  • cytotoxic lymphocyte maturation factor 40 kDa subunit
  • interleukin 12, p40
  • interleukin-12 beta chain
  • interleukin-12 subunit beta
  • natural killer cell stimulatory factor, 40 kD subunit
  • IL-12 p40
  • IL-23 subunit p40
  • interleukin-12 p40
  • IL-12B
  • interleukin-12 p40 subunit
  • IL-12 p40 subunit
  • interleukin-12p40
  • il-12p40.a
  • interleukin 12 p40.b
  • interleukin 12B
  • interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
  • interleukin 12Ba (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
  • interleukin 12 p40 subunit
  • interleukin-12 p40 chain
  • interleukin 12 40kDa subunit
  • Cytotoxic lymphocyte maturation factor 40 kDa subunit
  • Interleukin-12 subunit beta
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