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IL-10RA 产品

(Interleukin 10 Receptor, alpha (IL10RA))

Categories

The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009].

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Featured IL-10RA Categories

IL-10RA 抗体

High quality antibodies with extensive validation data.

IL-10RA ELISA试剂盒

Reliable ELISA kits for a wide range of species.

IL-10RA 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended IL-10RA 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (8)
Cat. No. ABIN7433870
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (7)
Cat. No. ABIN3022615
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC, IF
Validations
  • (4)
Cat. No. ABIN7259833
Quantity 200 μL
Datasheet Datasheet

Recommended IL-10RA ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6956986
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6956987
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6956988
Quantity 96 tests
Datasheet Datasheet

Recommended IL-10RA 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (5)
Cat. No. ABIN7274906
Quantity 100 μg
Datasheet Datasheet
Reactivity Cynomolgus
Source HEK-293 Cells
Validations
  • (4)
Cat. No. ABIN7274878
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7394459
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our IL-10RA Products

Mallikarjunappa, Shandilya, Sharma, Lamers, Bissonnette, Karrow, Meade: "Functional analysis of bovine interleukin-10 receptor alpha in response to Mycobacterium avium subsp. paratuberculosis lysate using CRISPR/Cas9." in: BMC genetics, Vol. 21, Issue 1, pp. 121, (2020) (PubMed).

Qiu, Gong, Xu, Cheng, Gao, Chen, Hu, Yang: "MYD88 L265P mutation promoted malignant B cell resistance against T cell-mediated cytotoxicity via upregulating the IL-10/STAT3 cascade." in: International immunopharmacology, Vol. 64, pp. 394-400, (2019) (PubMed).

Bhutiani, Li, Anderson, Gallagher, De Jesus, Singh, Jala, Fraig, Gu, Egilmez: "Enhanced gut barrier integrity sensitizes colon cancer to immune therapy." in: Oncoimmunology, Vol. 7, Issue 11, pp. e1498438, (2018) (PubMed).

Beck, Zobel, Barber, Evans, Lezina, Allchin, Blades, Elliott, Lord, Ashworth, Porter, Wagner: "Synthetic Lethal Screen Demonstrates That a JAK2 Inhibitor Suppresses a BCL6-dependent IL10RA/JAK2/STAT3 Pathway in High Grade B-cell Lymphoma." in: The Journal of biological chemistry, Vol. 291, Issue 32, pp. 16686-98, (2016) (PubMed).

Valle Oseguera, Spencer: "cmvIL-10 stimulates the invasive potential of MDA-MB-231 breast cancer cells." in: PLoS ONE, Vol. 9, Issue 2, pp. e88708, (2014) (PubMed).

Jiang, Lu, Yuan, Liu: "Regulation of interleukin-10 receptor ubiquitination and stability by beta-TrCP-containing ubiquitin E3 ligase." in: PLoS ONE, Vol. 6, Issue 11, pp. e27464, (2011) (PubMed).

Sundstedt, ONeill, Nicolson, Wraith: "Role for IL-10 in suppression mediated by peptide-induced regulatory T cells in vivo." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 3, pp. 1240-8, (2003) (PubMed).

Corinti, Albanesi, la Sala, Pastore, Girolomoni: "Regulatory activity of autocrine IL-10 on dendritic cell functions." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 7, pp. 4312-8, (2001) (PubMed).

Phillips, Parish, Drage, Cooke: "Cutting edge: interactions through the IL-10 receptor regulate autoimmune diabetes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 11, pp. 6087-91, (2001) (PubMed).

OFarrell, Liu, Moore, Mui: "IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways." in: The EMBO journal, Vol. 17, Issue 4, pp. 1006-18, (1998) (PubMed).

Synonyms and alternative names related to IL-10RA

interleukin 10 receptor subunit alpha (IL10RA), interleukin 10 receptor, alpha (Il10ra), interleukin 10 receptor subunit alpha (Il10ra), AW553859, CD210, CD210a, CDw210, CDW210A, CDw210a, HIL-10R, IL-10R1, IL10R, Il10r, IL10R1, IL10RA, mIL-10R

Protein level used designations for IL-10RA

  • interleukin 10 receptor 1
  • interleukin-10 receptor subunit alpha
  • interleukin 10 receptor, alpha
  • interleukin-10 receptor subunit alpha-like
  • IL-10 receptor subunit alpha
  • IL-10R subunit 1
  • IL-10R subunit alpha
  • IL-10RA
  • interleukin-10 receptor alpha chain
  • interleukin-10 receptor subunit 1
  • IL-10R1
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