IDH2 产品
(Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2))
Categories
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. [provided by RefSeq, Jul 2008].
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Featured IDH2 Categories
IDH2 抗体
High quality antibodies with extensive validation data.
IDH2 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
IDH2 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended IDH2 抗体
Product
Reactivity
Application
Validations
Cat. No.
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Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), IHC (fro), ICC
Validations
- (7)
Cat. No.
ABIN7441520
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP, IF, ChIP
Validations
- (1)
- (5)
Cat. No.
ABIN6142146
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC, FACS
Validations
- (6)
Cat. No.
ABIN7193379
Quantity
100 μL
Datasheet
Datasheet
Recommended IDH2 ELISA试剂盒
Product
Reactivity
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Cat. No.
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Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6957224
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Validations
Cat. No.
ABIN1138941
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1138942
Quantity
96 tests
Datasheet
Datasheet
Recommended IDH2 蛋白
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Reactivity
Source
Validations
Cat. No.
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Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1307372
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1307371
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7409158
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our IDH2 Products
: "IDH2 is a novel diagnostic and prognostic serum biomarker for non-small-cell lung cancer." in: Molecular oncology, Vol. 12, Issue 5, pp. 602-610, (2019) (PubMed).: "Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma. ..." in: Cancer discovery, Vol. 6, Issue 7, pp. 727-39, (2016) (PubMed).
: "Identification of proteins responsible for adriamycin resistance in breast cancer cells using proteomics analysis." in: Scientific reports, Vol. 5, pp. 9301, (2016) (PubMed).
: "Single muscle fiber proteomics reveals unexpected mitochondrial specialization." in: EMBO reports, Vol. 16, Issue 3, pp. 387-95, (2015) (PubMed).
: "Reductive carboxylation and 2-hydroxyglutarate formation by wild-type IDH2 in breast carcinoma cells." in: The international journal of biochemistry & cell biology, Vol. 65, pp. 125-33, (2015) (PubMed).
: "Altered global methylation and hydroxymethylation status in vulvar lichen sclerosus: further support for epigenetic mechanisms." in: The British journal of dermatology, Vol. 170, Issue 3, pp. 687-93, (2014) (PubMed).
: "Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer. ..." in: Nature, Vol. 513, Issue 7516, pp. 110-4, (2014) (PubMed).
: "D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice. ..." in: Genes & development, Vol. 28, Issue 5, pp. 479-90, (2014) (PubMed).
: "Elevated CO(2) levels cause mitochondrial dysfunction and impair cell proliferation." in: The Journal of biological chemistry, Vol. 286, Issue 43, pp. 37067-76, (2011) (PubMed).
: "Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value." in: Blood, Vol. 116, Issue 12, pp. 2122-6, (2010) (PubMed).
Synonyms and alternative names related to IDH2
isocitrate dehydrogenase subunit 2 (IDH2), isocitrate dehydrogenase (NADP(+)) 2, mitochondrial (IDH2), isocitrate dehydrogenase 2 (NADP+), mitochondrial (Idh2), isocitrate dehydrogenase (NADP(+)) 2, mitochondrial (Idh2), isocitrate dehydrogenase 2 (NADP+), mitochondrial S homeolog (idh2.S), isocitrate dehydrogenase 2 (NADP+), mitochondrial (idh2), isocitrate dehydrogenase [NADP], mitochondrial (LOC100441867), D2HGA2, E430004F23, F6P23.14, F6P23_14, ICD-M, IDH, Idh-2, IDH-II, idh2, IDH2, IDHM, IDP, IDPM, IDPm, isocitrate dehydrogenase II, isocitrate dehydrogenase subunit 2, mNADP-IDH, NAD+ DEPENDENT ISOCITRATE DEHYDROGENASE SUBUNIT 2, wu:fb33c06, wu:fk31e05, wu:fq43b01, zgc:55485Protein level used designations for IDH2
- NADP(+)-specific ICDH
- isocitrate dehydrogenase [NADP], mitochondrial
- oxalosuccinate decarboxylase
- ICD-M
- IDH
- IDP
- NADP+-specific isocitrate dehydrogenase
- NADPH-specific isocitrate dehydrogenase
- isocitrate dehydrogenase 2 (NADP+), mitochondrial
- isocitrate dehydrogenase [NADP], mitochondrial-like
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