IDH1 抗体
(Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1))
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. [provided by RefSeq, Jul 2008].
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Cat. No.
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Latest Publications for our IDH1 抗体
: "lncRNA Ftx promotes aerobic glycolysis and tumor progression through the PPARγ pathway in hepatocellular carcinoma." in: International journal of oncology, Vol. 53, Issue 2, pp. 551-566, (2018) (PubMed).: "AMP-Activated Protein Kinase α2 in Neutrophils Regulates Vascular Repair via Hypoxia-Inducible Factor-1α and a Network of Proteins Affecting Metabolism and Apoptosis." in: Circulation research, Vol. 120, Issue 1, pp. 99-109, (2016) (PubMed).
: "Identification of proteins responsible for adriamycin resistance in breast cancer cells using proteomics analysis." in: Scientific reports, Vol. 5, pp. 9301, (2016) (PubMed).
: "DIGE based proteome analysis of mammary gland tissue in water buffalo (Bubalus bubalis): Lactating vis-a-vis heifer." in: Journal of proteomics, Vol. 119C, pp. 100-111, (2015) (PubMed).
: "A high-throughput fluorimetric assay for 2-hydroxyglutarate identifies Zaprinast as a glutaminase inhibitor." in: Cancer discovery, Vol. 4, Issue 7, pp. 828-39, (2014) (PubMed).
: "The proteomics of colorectal cancer: identification of a protein signature associated with prognosis." in: PLoS ONE, Vol. 6, Issue 11, pp. e27718, (2011) (PubMed).
: "Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value." in: Blood, Vol. 116, Issue 12, pp. 2122-6, (2010) (PubMed).
Aliases for IDH1 抗体
isocitrate dehydrogenase (NADP(+)) 1, cytosolic (IDH1) 抗体isocitrate dehydrogenase 1 (NADP+), soluble (Idh1) 抗体
isocitrate dehydrogenase (NADP(+)) 1, cytosolic (Idh1) 抗体
isocitrate dehydrogenase 1 (NADP+) L homeolog (idh1.L) 抗体
isocitrate dehydrogenase 1 (NADP+), soluble (idh1) 抗体
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