IDH1 产品
(Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1))
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Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. [provided by RefSeq, Jul 2008].
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Featured IDH1 Categories
IDH1 抗体
High quality antibodies with extensive validation data.
IDH1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
IDH1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended IDH1 抗体
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Reactivity
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Human
Application
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Cat. No.
ABIN3023106
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
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- (10)
Cat. No.
ABIN7436579
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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- (7)
Cat. No.
ABIN7268027
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Datasheet
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Recommended IDH1 ELISA试剂盒
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Cat. No.
ABIN6574327
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Rat
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- (1)
Cat. No.
ABIN6957223
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96 tests
Datasheet
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Mouse
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ABIN581788
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96 tests
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Recommended IDH1 蛋白
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Escherichia coli (E. coli)
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Cat. No.
ABIN7274843
Quantity
100 μg
Datasheet
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Reactivity
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Escherichia coli (E. coli)
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- (1)
Cat. No.
ABIN7123639
Quantity
50 μg
Datasheet
Datasheet
Reactivity
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Source
Escherichia coli (E. coli)
Validations
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Cat. No.
ABIN7123640
Quantity
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Latest Publications for our IDH1 Products
: "Serological Biomarkers for Early Detection of Hepatocellular Carcinoma: A Focus on Autoantibodies against Tumor-Associated Antigens Encoded by Cancer Driver Genes." in: Cancers, Vol. 12, Issue 5, (2020) (PubMed).: "IDH2 is a novel diagnostic and prognostic serum biomarker for non-small-cell lung cancer." in: Molecular oncology, Vol. 12, Issue 5, pp. 602-610, (2019) (PubMed).
: "lncRNA Ftx promotes aerobic glycolysis and tumor progression through the PPARγ pathway in hepatocellular carcinoma." in: International journal of oncology, Vol. 53, Issue 2, pp. 551-566, (2018) (PubMed).
: "AMP-Activated Protein Kinase α2 in Neutrophils Regulates Vascular Repair via Hypoxia-Inducible Factor-1α and a Network of Proteins Affecting Metabolism and Apoptosis." in: Circulation research, Vol. 120, Issue 1, pp. 99-109, (2016) (PubMed).
: "Identification of proteins responsible for adriamycin resistance in breast cancer cells using proteomics analysis." in: Scientific reports, Vol. 5, pp. 9301, (2016) (PubMed).
: "DIGE based proteome analysis of mammary gland tissue in water buffalo (Bubalus bubalis): Lactating vis-a-vis heifer." in: Journal of proteomics, Vol. 119C, pp. 100-111, (2015) (PubMed).
: "The effects of PGC-1α on the proliferation and energy metabolism of malignant endometrial cancer cells." in: OncoTargets and therapy, Vol. 8, pp. 769-74, (2015) (PubMed).
: "Effective immuno-targeting of the IDH1 mutation R132H in a murine model of intracranial glioma." in: Acta neuropathologica communications, Vol. 3, pp. 4, (2015) (PubMed).
: "A high-throughput fluorimetric assay for 2-hydroxyglutarate identifies Zaprinast as a glutaminase inhibitor." in: Cancer discovery, Vol. 4, Issue 7, pp. 828-39, (2014) (PubMed).
: "IDH1 regulates phospholipid metabolism in developing astrocytes." in: Neuroscience letters, Vol. 582, pp. 87-92, (2014) (PubMed).
Synonyms and alternative names related to IDH1
isocitrate dehydrogenase (NADP(+)) 1, cytosolic (IDH1), isocitrate dehydrogenase 1 (NADP+), soluble (Idh1), isocitrate dehydrogenase (NADP(+)) 1, cytosolic (Idh1), isocitrate dehydrogenase 1 (NADP+) L homeolog (idh1.L), isocitrate dehydrogenase 1 (NADP+), soluble (idh1), isocitrate dehydrogenase 1 (IDH1), AI314845, AI788952, cb876, E030024J03Rik, F23E12.180, F23E12_180, fm90e09, Id-1, IDCD, IDH, Idh-1, IDH-I, IDP, IDPC, Idpc, im:7143416, isocitrate dehydrogenase 1, isocitrate dehydrogenase I, NAD+ DEPENDENT ISOCITRATE DEHYDROGENASE SUBUNIT 1, NADP-CICDH, PICD, wu:fm90e09Protein level used designations for IDH1
- NADP(+)-specific ICDH
- NADP-dependent isocitrate dehydrogenase, cytosolic
- NADP-dependent isocitrate dehydrogenase, peroxisomal
- isocitrate dehydrogenase [NADP] cytoplasmic
- oxalosuccinate decarboxylase
- IDH
- IDP
- cytosolic NADP-isocitrate dehydrogenase
- isocitrate dehydrogenase 1 (NADP+), soluble
- isocitrate dehydrogenase [NADP] cytoplasmic-like
- Isocitrate dehydrogenase 1, soluble
- isocitrate dehydrogenase 1
- IDH-I
- Isocitric dehydrogenase 1
- NAD(+)-specific ICDH 1
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