HSD11B2 产品
(Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2))
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There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010].
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Featured HSD11B2 Categories
HSD11B2 抗体
High quality antibodies with extensive validation data.
HSD11B2 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
HSD11B2 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended HSD11B2 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Horse, Mouse, Rat
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (4)
- (7)
Cat. No.
ABIN701680
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Rat
Application
WB, IHC
Validations
- (4)
Cat. No.
ABIN7264121
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP
Validations
- (3)
Cat. No.
ABIN516707
Quantity
100 μL
Datasheet
Datasheet
Recommended HSD11B2 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (2)
- (1)
Cat. No.
ABIN6956636
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6956637
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative
Validations
- (1)
Cat. No.
ABIN1049562
Quantity
96 tests
Datasheet
Datasheet
Recommended HSD11B2 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1307105
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1307107
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7407292
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our HSD11B2 Products
: "A novel derivatives of thiazol-4(5H)-one and their activity in the inhibition of 11β-hydroxysteroid dehydrogenase type 1." in: Bioorganic chemistry, Vol. 79, pp. 115-121, (2019) (PubMed).: "Prenatal maternal distress affects atopic dermatitis in offspring mediated by oxidative stress." in: The Journal of allergy and clinical immunology, Vol. 138, Issue 2, pp. 468-475.e5, (2016) (PubMed).
: "Regulation of glucocorticoid-related genes and receptors/regulatory enzyme expression in intrauterine growth restriction filial rats." in: Life sciences, Vol. 150, pp. 61-6, (2016) (PubMed).
: "Preeclampsia induced by cadmium in rats is related to abnormal local glucocorticoid synthesis in placenta." in: Reproductive biology and endocrinology : RB&E, Vol. 12, pp. 77, (2015) (PubMed).
: "Preeclampsia is associated with a deficiency of lipoxin A4, an endogenous anti-inflammatory mediator." in: Fertility and sterility, Vol. 102, Issue 1, pp. 282-290.e4, (2014) (PubMed).
Synonyms and alternative names related to HSD11B2
hydroxysteroid (11-beta) dehydrogenase 2 L homeolog (hsd11b2.L), hydroxysteroid 11-beta dehydrogenase 2 (HSD11B2), hydroxysteroid 11-beta dehydrogenase 2 (Hsd11b2), 11-HSD2, 11HSD2, AME, AME1, HSD2, HSD11B2, HSD11K, MGC81883, SDR9C3Protein level used designations for HSD11B2
- hydroxysteroid (11-beta) dehydrogenase 2
- corticosteroid 11-beta-dehydrogenase isozyme 2
- 11 beta-hydroxysteroid dehydrogenase type 2
- -HSD11 type II
- 11-DH2
- 11-beta-HSD2
- 11-beta-hydroxysteroid dehydrogenase type 2
- 11-beta-hydroxysteroid dehydrogenase type II
- NAD-dependent 11-beta-hydroxysteroid dehydrogenase
- short chain dehydrogenase/reductase family 9C member 3
- 11-beta hydroxysteroid dehydrogenase
- hydroxysteroid 11-beta dehydrogenase 2
- 11-beta-hydroxysteroid dehydrogenase 2
- 11(beta)-HSD2
- Hydroxysteroid dehydrogenase, 11 beta type 2
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