In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the downstream homeobox A9 (HOXA9) gene. [provided by RefSeq, Mar 2011].
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Gordon, Hassan, Saini, Montecino, van Wijnen, Stein, Stein, Lian: "Pbx1 represses osteoblastogenesis by blocking Hoxa10-mediated recruitment of chromatin remodeling factors." in: Molecular and cellular biology, Vol. 30, Issue 14, pp. 3531-41, (2010) (PubMed).
Das: "Regional development of uterine decidualization: molecular signaling by Hoxa-10." in: Molecular reproduction and development, Vol. 77, Issue 5, pp. 387-96, (2010) (PubMed).
Vinagre, Moncaut, Carapuço, Nóvoa, Bom, Mallo: "Evidence for a myotomal Hox/Myf cascade governing nonautonomous control of rib specification within global vertebral domains." in: Developmental cell, Vol. 18, Issue 4, pp. 655-61, (2010) (PubMed).
Ko, Lengyel, Naora: "The Müllerian HOXA10 gene promotes growth of ovarian surface epithelial cells by stimulating epithelial-stromal interactions." in: Molecular and cellular endocrinology, Vol. 317, Issue 1-2, pp. 112-9, (2010) (PubMed).
Sugimoto, Nakamura, Okinaka, Hirano, Ono, Shigeno, Shinjo, Ohnishi: "HOXA10 expression induced by Abl kinase inhibitors enhanced apoptosis through PI3K pathway in CML cells." in: Leukemia research, Vol. 32, Issue 6, pp. 962-71, (2008) (PubMed).
