HNRNPU 抗体
(Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A) (HNRNPU))
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008].
recommended
recommended
recommended
HNRNPU 适用: 人, 小鼠, 猴 WB, ELISA, IP, IF, IHC (p), FACS, ICC 宿主: 小鼠 Monoclonal 3G6 unconjugated
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Popular HNRNPU 抗体
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Reactivity
Application
Validations
Cat. No.
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Datasheet
Reactivity
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Application
WB, IHC, IP, IF
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Cat. No.
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Datasheet
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Application
WB, IHC, IP, IF
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Cat. No.
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Quantity
100 μg
Datasheet
Datasheet
Reactivity
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Application
WB, ELISA, IP, IF, IHC (p), FACS, ICC
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Cat. No.
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Cat. No.
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Quantity
100 μg
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Reactivity
Human, Mouse, Rat
Application
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Cat. No.
ABIN1387279
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Human, Mouse, Rabbit, Rat
Application
WB, IHC
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Cat. No.
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Quantity
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Cat. No.
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Quantity
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Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
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Cat. No.
ABIN7260907
Quantity
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Datasheet
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Cow, Dog, Guinea Pig, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
Application
WB
Validations
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Cat. No.
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Datasheet
Datasheet
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Application
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Validations
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Cat. No.
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Quantity
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Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
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Validations
Cat. No.
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Quantity
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Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
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Validations
Cat. No.
ABIN1400787
Quantity
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Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IF (p)
Validations
Cat. No.
ABIN1400788
Quantity
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Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IF (p)
Validations
Cat. No.
ABIN1400789
Quantity
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Datasheet
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Latest Publications for our HNRNPU 抗体
: "Hypertonic Stress Causes Cytoplasmic Translocation of Neuronal, but Not Astrocytic, FUS due to Impaired Transportin Function." in: Cell reports, Vol. 24, Issue 4, pp. 987-1000.e7, (2018) (PubMed).: "A Prader-Willi locus lncRNA cloud modulates diurnal genes and energy expenditure." in: Human molecular genetics, Vol. 22, Issue 21, pp. 4318-28, (2013) (PubMed).
: "The nuclear scaffold protein SAF-A is required for kinetochore-microtubule attachment and contributes to the targeting of Aurora-A to mitotic spindles." in: Journal of cell science, Vol. 124, Issue Pt 3, pp. 394-404, (2011) (PubMed).
: "MicroRNA-binding is required for recruitment of human Argonaute 2 to stress granules and P-bodies." in: Biochemical and biophysical research communications, Vol. 414, Issue 1, pp. 259-64, (2011) (PubMed).
: "In neurons, activity-dependent association of dendritically transported mRNA transcripts with the transacting factor CBF-A is mediated by A2RE/RTS elements." in: Molecular biology of the cell, Vol. 22, Issue 11, pp. 1864-77, (2011) (PubMed).
: "MicroRNA expression profiles of human blood monocyte-derived dendritic cells and macrophages reveal miR-511 as putative positive regulator of Toll-like receptor 4." in: The Journal of biological chemistry, Vol. 286, Issue 30, pp. 26487-95, (2011) (PubMed).
: "Preferential repair of oxidized base damage in the transcribed genes of mammalian cells." in: The Journal of biological chemistry, Vol. 286, Issue 8, pp. 6006-16, (2011) (PubMed).
: "Identification of a heterogeneous nuclear ribonucleoprotein-recognition region in the HIV Rev protein." in: The Journal of biological chemistry, Vol. 284, Issue 48, pp. 33384-91, (2009) (PubMed).
: "Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation." in: The Journal of biological chemistry, Vol. 281, Issue 32, pp. 23180-90, (2006) (PubMed).
: "Kruppel-like factor 2 transcriptional regulation involves heterogeneous nuclear ribonucleoproteins and acetyltransferases." in: Biochemistry, Vol. 44, Issue 16, pp. 6276-85, (2005) (PubMed).
Aliases for HNRNPU 抗体
heterogeneous nuclear ribonucleoprotein U (Hnrnpu) 抗体heterogeneous nuclear ribonucleoprotein U (HNRNPU) 抗体
heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) S homeolog (hnrnpu.S) 抗体
heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) (HNRNPU) 抗体
AA408410 抗体
AI256620 抗体
AL024194 抗体
AL024437 抗体
AW557595 抗体
C86794 抗体
hnRNP U 抗体
Hnrpu 抗体
HNRPU 抗体
SAF-A 抗体
saf-a 抗体
SAFA 抗体
SN1 抗体
Sp120 抗体
U21.1 抗体
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