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HNRNPU 产品

(Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A) (HNRNPU))
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008].

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Featured HNRNPU Categories

HNRNPU 抗体

High quality antibodies with extensive validation data.

HNRNPU ELISA试剂盒

Reliable ELISA kits for a wide range of species.

HNRNPU 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended HNRNPU 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, IF
Validations
  • (7)
Cat. No. ABIN7101656
Quantity 20 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, IF
Validations
  • (7)
Cat. No. ABIN1680323
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Monkey, Mouse
Application WB, ELISA, IP, IF, IHC (p), FACS, ICC
Validations
  • (8)
  • (2)
Cat. No. ABIN108578
Quantity 50 μL
Datasheet Datasheet

Recommended HNRNPU ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6967387
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6956516
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1136578
Quantity 96 tests
Datasheet Datasheet

Recommended HNRNPU 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1306883
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7398272
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2722939
Quantity 20 μg
Datasheet Datasheet

Latest Publications for our HNRNPU Products

Hock, Maniecka, Hruska-Plochan, Reber, Laferrière, Sahadevan M K, Ederle, Gittings, Pelkmans, Dupuis, Lashley, Ruepp, Dormann, Polymenidou: "Hypertonic Stress Causes Cytoplasmic Translocation of Neuronal, but Not Astrocytic, FUS due to Impaired Transportin Function." in: Cell reports, Vol. 24, Issue 4, pp. 987-1000.e7, (2018) (PubMed).

Powell, Coulson, Crary, Wong, Ach, Tsang, Alice Yamada, Yasui, Lasalle: "A Prader-Willi locus lncRNA cloud modulates diurnal genes and energy expenditure." in: Human molecular genetics, Vol. 22, Issue 21, pp. 4318-28, (2013) (PubMed).

Ma, Matsunaga, Morimoto, Sakashita, Urano, Uchiyama, Fukui: "The nuclear scaffold protein SAF-A is required for kinetochore-microtubule attachment and contributes to the targeting of Aurora-A to mitotic spindles." in: Journal of cell science, Vol. 124, Issue Pt 3, pp. 394-404, (2011) (PubMed).

Pare, López-Orozco, Hobman: "MicroRNA-binding is required for recruitment of human Argonaute 2 to stress granules and P-bodies." in: Biochemical and biophysical research communications, Vol. 414, Issue 1, pp. 259-64, (2011) (PubMed).

Raju, Fukuda, López-Iglesias, Göritz, Visa, Percipalle: "In neurons, activity-dependent association of dendritically transported mRNA transcripts with the transacting factor CBF-A is mediated by A2RE/RTS elements." in: Molecular biology of the cell, Vol. 22, Issue 11, pp. 1864-77, (2011) (PubMed).

Tserel, Runnel, Kisand, Pihlap, Bakhoff, Kolde, Peterson, Vilo, Peterson, Rebane: "MicroRNA expression profiles of human blood monocyte-derived dendritic cells and macrophages reveal miR-511 as putative positive regulator of Toll-like receptor 4." in: The Journal of biological chemistry, Vol. 286, Issue 30, pp. 26487-95, (2011) (PubMed).

Banerjee, Mandal, Das, Hegde, Das, Bhakat, Boldogh, Sarkar, Mitra, Hazra: "Preferential repair of oxidized base damage in the transcribed genes of mammalian cells." in: The Journal of biological chemistry, Vol. 286, Issue 8, pp. 6006-16, (2011) (PubMed).

Hadian, Vincendeau, Mäusbacher, Nagel, Hauck, Ueffing, Loyter, Werner, Wolff, Brack-Werner: "Identification of a heterogeneous nuclear ribonucleoprotein-recognition region in the HIV Rev protein." in: The Journal of biological chemistry, Vol. 284, Issue 48, pp. 33384-91, (2009) (PubMed).

Uchimura, Ichimura, Uwada, Tachibana, Sugahara, Nakao, Saitoh: "Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation." in: The Journal of biological chemistry, Vol. 281, Issue 32, pp. 23180-90, (2006) (PubMed).

Ahmad, Lingrel: "Kruppel-like factor 2 transcriptional regulation involves heterogeneous nuclear ribonucleoproteins and acetyltransferases." in: Biochemistry, Vol. 44, Issue 16, pp. 6276-85, (2005) (PubMed).

Synonyms and alternative names related to HNRNPU

heterogeneous nuclear ribonucleoprotein U (Hnrnpu), heterogeneous nuclear ribonucleoprotein U (HNRNPU), heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) S homeolog (hnrnpu.S), heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) (HNRNPU), AA408410, AI256620, AL024194, AL024437, AW557595, C86794, hnRNP U, Hnrpu, HNRPU, SAF-A, saf-a, SAFA, SN1, Sp120, U21.1

Protein level used designations for HNRNPU

  • SAF-A
  • heterogenous nuclear ribonucleoprotein U
  • nuclear matrix protein sp120
  • scaffold attachment factor A
  • system N1 Na+ and H+-coupled glutamine transporter
  • transporter protein
  • transporter protein; system N1 Na+ and H+-coupled glutamine transporter
  • heterogeneous nuclear ribonucleoprotein U
  • p120 nuclear protein
  • pp120
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