HMGCR 抗体
(3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
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recommended
recommended
HMGCR 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
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Reactivity
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Validations
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Datasheet
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Application
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Cat. No.
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Quantity
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Application
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Cat. No.
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Quantity
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Datasheet
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Quantity
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Datasheet
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Cat. No.
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Quantity
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Datasheet
Datasheet
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Application
WB, ELISA, IHC, IF, ICC
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Cat. No.
ABIN6262303
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
WB, ELISA, FACS, IF (cc), IF (p), IHC (fro), IHC (p)
Validations
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Quantity
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Cat. No.
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Quantity
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Quantity
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Cat. No.
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Reactivity
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Cat. No.
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Datasheet
Datasheet
Reactivity
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Application
WB, FACS, IF (cc), IF (p)
Validations
Cat. No.
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Quantity
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Datasheet
Datasheet
Reactivity
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Application
WB, FACS, IF (cc), IF (p)
Validations
Cat. No.
ABIN901017
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
WB, FACS, IF (cc), IF (p)
Validations
Cat. No.
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Quantity
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Datasheet
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Reactivity
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Application
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Validations
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Quantity
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Datasheet
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Latest Publications for our HMGCR 抗体
: "Fluvastatin is effective against thymic carcinoma." in: Life sciences, Vol. 240, pp. 117110, (2020) (PubMed).: "MicroRNA-148a deficiency promotes hepatic lipid metabolism and hepatocarcinogenesis in mice." in: Cell death & disease, Vol. 8, Issue 7, pp. e2916, (2018) (PubMed).
: "Hempseed Peptides Exert Hypocholesterolemic Effects with a Statin-Like Mechanism." in: Journal of agricultural and food chemistry, Vol. 65, Issue 40, pp. 8829-8838, (2017) (PubMed).
: "Effects of sepsis on the metabolism of sphingomyelin and cholesterol in mice with liver dysfunction." in: Experimental and therapeutic medicine, Vol. 14, Issue 6, pp. 5635-5640, (2017) (PubMed).
: "Leoligin, the major lignan from Edelweiss, inhibits 3-hydroxy-3-methyl-glutaryl-CoA reductase and reduces cholesterol levels in ApoE-/- mice." in: Journal of molecular and cellular cardiology, Vol. 99, pp. 35-46, (2016) (PubMed).
: "Ethanol extract of Pinus koraiensis leaves containing lambertianic acid exerts anti-obesity and hypolipidemic effects by activating adenosine monophosphate-activated protein kinase (AMPK)." in: BMC complementary and alternative medicine, Vol. 16, pp. 51, (2016) (PubMed).
: "Effects of SIRT1 gene knock-out via activation of SREBP2 protein-mediated PI3K/AKT signaling on osteoarthritis in mice." in: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, Vol. 36, Issue 5, pp. 683-690, (2016) (PubMed).
: "Synergetic cholesterol-lowering effects of main alkaloids from Rhizoma Coptidis in HepG2 cells and hypercholesterolemia hamsters." in: Life sciences, Vol. 151, pp. 50-60, (2016) (PubMed).
: "Tumor-specific expression of HMG-CoA reductase in a population-based cohort of breast cancer patients." in: BMC clinical pathology, Vol. 15, pp. 8, (2015) (PubMed).
: "The antihypercholesterolemic effect of jatrorrhizine isolated from Rhizoma Coptidis." in: Phytomedicine : international journal of phytotherapy and phytopharmacology, Vol. 21, Issue 11, pp. 1373-81, (2014) (PubMed).
Aliases for HMGCR 抗体
3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) 抗体3-hydroxy-3-methylglutaryl-CoA reductase L homeolog (hmgcr.L) 抗体
3-hydroxy-3-methylglutaryl-Coenzyme A reductase (Hmgcr) 抗体
3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr) 抗体
HMG Coenzyme A reductase (Hmgcr) 抗体
3-hydroxy-3-methylglutaryl-CoA reductase b (hmgcrb) 抗体
3H3M 抗体
BcDNA:LD15354 抗体
bro1 抗体
bs32f05.y1 抗体
CG10367 抗体
Clb 抗体
clb 抗体
Dmel\\CG10367 抗体
DmHMG-CoAr 抗体
Hmg 抗体
hmg-coa-r 抗体
HMG-CoAR 抗体
HmG-CoAR 抗体
hmgc 抗体
HMGCoAR 抗体
HMGCoAr 抗体
HMGCoARr 抗体
HMGCR 抗体
hmgcr 抗体
hmgcr2 抗体
HMGCR_Dm 抗体
HMGR 抗体
hmgrc 抗体
im:6912716 抗体
l(3)01152 抗体
l(3)04684 抗体
LDLCQ3 抗体
Red 抗体
zgc:110746 抗体
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