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HLA-DRB5 ELISA试剂盒

(Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5))

HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008].

recommended

HLA-DRB5 ELISA 试剂盒 (ABIN6968427)

HLA-DRB5 适用: 人 Colorimetric Competition ELISA 1.563 ng/mL - 100 ng/mL Plasma, Serum, Tissue Homogenate

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Popular HLA-DRB5 ELISA试剂盒

Product

Reactivity

Analytical Method

Validations

Cat. No.

Quantity

Datasheet

HLA-DRB5 ELISA 试剂盒

Reactivity Human

Analytical Method Quantitative Competition ELISA

Validations

Cat. No. ABIN6968427

Quantity 96 tests

Datasheet Datasheet

Aliases for HLA-DRB5 ELISA试剂盒

major histocompatibility complex, class II, DR beta 5 (HLA-DRB5) ELISA试剂盒
HLA-DRB ELISA试剂盒

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