HLA-DRB3 产品
(Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3))
Categories
HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008].
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Featured HLA-DRB3 Categories
HLA-DRB3 抗体
High quality antibodies with extensive validation data.
HLA-DRB3 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended HLA-DRB3 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, FACS
Validations
- (4)
Cat. No.
ABIN516514
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
IHC
Validations
- (3)
Cat. No.
ABIN7258926
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (2)
Cat. No.
ABIN7155605
Quantity
100 μg
Datasheet
Datasheet
Recommended HLA-DRB3 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1306765
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our HLA-DRB3 Products
: "Cell cycle effects by C-FADD depend on its C-terminal phosphorylation site." in: The Journal of biological chemistry, Vol. 278, Issue 43, pp. 41585-8, (2003) (PubMed).: "A function of Fas-associated death domain protein in cell cycle progression localized to a single amino acid at its C-terminal region." in: Immunity, Vol. 18, Issue 4, pp. 513-21, (2003) (PubMed).
Synonyms and alternative names related to HLA-DRB3
major histocompatibility complex, class II, DR beta 3 (HLA-DRB3), major histocompatibility complex, class II, DRB3 (BOLA-DRB3), BLA-DRB3, Bota-DRB01, Bota-DRB02, Bota-DRB04, Bota-DRB07, Bota-DRB21, Bota-DRB22, HLA-DR3B, LA-DRBProtein level used designations for HLA-DRB3
- DR7
- HLA class II histocompatibility antigen, DR beta 3 chain
- HLA class II histocompatibility antigen, DRB1-7 beta chain
- MHC class II HLA-DR beta 3 chain
- MHC class II antigen DR beta 3 chain
- MHC class II antigen DRB3
- human leucocyte antigen DRB3
- BoLA-DRB3.2
- DR beta-chain antigen binding domain
- DR-beta chain MHC class II
- MHC class II DR beta chain
- MHC class II DRB3
- MHC class II antigen BoLA-DRB3
- MHC class II antigen beta chain
- MHC class II leukocyte antigen BoLA-DRB3
- MHC(BoLA) class II DR-beta chain
- histocompatibility complex, class II, DR beta 3
- leukocyte antigen DRB3
- major histocompatibility complex class II DR-beta chain
- major histocompatibility complex, class II, DR beta 3
- major histocompatibility complex, class II, DRB3
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