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HLA-DRB1 抗体

(Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1))
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide\; exons 2 and 3 encode the two extracellular domains\; exon 4 encodes the transmembrane domain\; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008].
HLA-DRB1 抗体  (AA 30-266) HLA-DRB1 抗体  (AA 30-266) HLA-DRB1 抗体 (AA 30-266) (ABIN7440764)

HLA-DRB1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

HLA-DRB1 抗体 HLA-DRB1 抗体 HLA-DRB1 抗体 (ABIN6939640)

HLA-DRB1 适用: 人, 猴 WB, FACS, IF, IHC, ISt, StM 宿主: 小鼠 Monoclonal LN-3 unconjugated

HLA-DRB1 抗体  (AA 27-264) HLA-DRB1 抗体  (AA 27-264) HLA-DRB1 抗体 (AA 27-264) (ABIN7440767)

HLA-DRB1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

HLA-DRB1 抗体 by 适用

Find HLA-DRB1 抗体 for a variety of species such as anti-Human HLA-DRB1, anti-Monkey HLA-DRB1, anti-Baboon HLA-DRB1. The species listed below are among those available. Click on a link to go to the corresponding products.

HLA-DRB1 抗体 by 应用范围

Find HLA-DRB1 抗体 validated for a specific application such as WB, FACS, IF, ELISA. Some of the available applications are listed below. Click on a link to go to the corresponding products.

HLA-DRB1 抗体 by 抗体来源

Find HLA-DRB1 抗体 with a specific 抗体来源. The 抗体来源 listed below are among those available. Click on a link to go to the corresponding products.

HLA-DRB1 抗体 by 抗原表位

Find HLA-DRB1 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

HLA-DRB1 抗体 by 克隆形成能力

Find available monoclonal or polyclonal HLA-DRB1 抗体. Click on a link to go to the corresponding products.

HLA-DRB1 抗体 by 克隆

Find HLA-DRB1 抗体 with a specific 克隆. The 克隆 listed below are among those available. Click on a link to go to the corresponding products.

HLA-DRB1 抗体 by 标记

Find HLA-DRB1 抗体 with a specific conjugate such as Biotin, FITC, HRP. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular HLA-DRB1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (7)
Cat. No. ABIN7440764
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Monkey
Application WB, FACS, IF, IHC, ISt, StM
Validations
  • (6)
Cat. No. ABIN6939640
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Application WB, IHC, IP, ICC
Validations
  • (5)
Cat. No. ABIN7440767
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF, IHC, IHC (p), ICC
Validations
  • (1)
  • (3)
Cat. No. ABIN2855994
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
  • (2)
Cat. No. ABIN516510
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application IHC
Validations
  • (3)
Cat. No. ABIN7477493
Quantity 1 mL
Datasheet Datasheet
Reactivity Human
Application WB, FACS, IHC (p)
Validations
  • (4)
Cat. No. ABIN390872
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF, ELISA
Validations
  • (2)
Cat. No. ABIN7155613
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7155618
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7246556
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC
Validations
  • (2)
Cat. No. ABIN7268374
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Monkey
Application WB, FACS, IF, ISt, IHC (f)
Validations
  • (3)
Cat. No. ABIN6186381
Quantity 50 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN6262291
Quantity 100 μL
Datasheet Datasheet
Reactivity Baboon, Chimpanzee, Dog, Human, Monkey, Squirrel
Application FACS, IF
Validations
  • (1)
Cat. No. ABIN6939645
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application IF
Validations
  • (1)
Cat. No. ABIN7263685
Quantity 200 μL
Datasheet Datasheet

Latest Publications for our HLA-DRB1 抗体

Andrés-Benito, Moreno, Aso, Povedano, Ferrer: "Amyotrophic lateral sclerosis, gene deregulation in the anterior horn of the spinal cord and frontal cortex area 8: implications in frontotemporal lobar degeneration." in: Aging, Vol. 9, Issue 3, pp. 823-851, (2017) (PubMed).

Cao, Schmitz, Yang, Hogan, Bunch, Hu, Jennette, Berg, Arnett, Jennette, Falk, Preston: "DRB1*15 allele is a risk factor for PR3-ANCA disease in African Americans." in: Journal of the American Society of Nephrology : JASN, Vol. 22, Issue 6, pp. 1161-7, (2011) (PubMed).

von Salomé, Gyllensten, Bergström: "Full-length sequence analysis of the HLA-DRB1 locus suggests a recent origin of alleles." in: Immunogenetics, Vol. 59, Issue 4, pp. 261-71, (2007) (PubMed).

Raymond, Kas, Paddock, Qiu, Zhou, Subramanian, Chang, Palmieri, Haugen, Kaul, Olson: "Ancient haplotypes of the HLA Class II region." in: Genome research, Vol. 15, Issue 9, pp. 1250-7, (2005) (PubMed).

Coppin, Avoustin, Fabron, Huchenq, Garnier, Thomsen, De Preval: "Evolution of the HLA-DR1 gene family. Structural and functional analysis of the new allele "DR-BON"." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 144, Issue 3, pp. 984-9, (1990) (PubMed).

Bell, Estess, St John, Saiki, Watling, Erlich, McDevitt: "DNA sequence and characterization of human class II major histocompatibility complex beta chains from the DR1 haplotype." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 82, Issue 10, pp. 3405-9, (1985) (PubMed).

Aliases for HLA-DRB1 抗体

major histocompatibility complex, class II, DR beta 1 (hla-drb1) 抗体
major histocompatibility complex, class II, DR beta 1 (HLA-DRB1) 抗体
DRB1 抗体
DRw10 抗体
HLA-DR1B 抗体
HLA-DRB 抗体
MGC108235 抗体
SS1 抗体
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